Literature DB >> 23229471

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe.

E M Brouwer-Brolsma1, H A Bischoff-Ferrari, R Bouillon, E J M Feskens, C J Gallagher, E Hypponen, D J Llewellyn, E Stoecklin, J Dierkes, A K Kies, F J Kok, C Lamberg-Allardt, U Moser, S Pilz, W H Saris, N M van Schoor, P Weber, R Witkamp, A Zittermann, L C P G M de Groot.   

Abstract

UNLABELLED: On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized.
INTRODUCTION: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive.
METHODS: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized.
RESULTS: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population.
CONCLUSION: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.

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Year:  2012        PMID: 23229471     DOI: 10.1007/s00198-012-2231-3

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  92 in total

1.  Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults.

Authors:  Heike A Bischoff-Ferrari; Thomas Dietrich; E John Orav; Bess Dawson-Hughes
Journal:  Am J Med       Date:  2004-05-01       Impact factor: 4.965

Review 2.  Vitamin D deficiency.

Authors:  Michael F Holick
Journal:  N Engl J Med       Date:  2007-07-19       Impact factor: 91.245

3.  Vitamin D and cognitive impairment in the elderly U.S. population.

Authors:  David J Llewellyn; Iain A Lang; Kenneth M Langa; David Melzer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-11-01       Impact factor: 6.053

4.  Vitamin D dose requirements for fracture prevention.

Authors:  Andrew Grey; Mark J Bolland; Ian R Reid
Journal:  N Engl J Med       Date:  2012-10-04       Impact factor: 91.245

Review 5.  The role of falls in fracture prediction.

Authors:  Heike A Bischoff-Ferrari
Journal:  Curr Osteoporos Rep       Date:  2011-09       Impact factor: 5.096

Review 6.  The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.

Authors:  Anastassios G Pittas; Joseph Lau; Frank B Hu; Bess Dawson-Hughes
Journal:  J Clin Endocrinol Metab       Date:  2007-03-27       Impact factor: 5.958

Review 7.  Molecular mechanisms of vitamin D action.

Authors:  Mark R Haussler; G Kerr Whitfield; Ichiro Kaneko; Carol A Haussler; David Hsieh; Jui-Cheng Hsieh; Peter W Jurutka
Journal:  Calcif Tissue Int       Date:  2012-07-11       Impact factor: 4.333

8.  High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.

Authors:  An Lehouck; Chantal Mathieu; Claudia Carremans; Femke Baeke; Jan Verhaegen; Johan Van Eldere; Brigitte Decallonne; Roger Bouillon; Marc Decramer; Wim Janssens
Journal:  Ann Intern Med       Date:  2012-01-17       Impact factor: 25.391

9.  Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies.

Authors:  Armin Zittermann; Simona Iodice; Stefan Pilz; William B Grant; Vincenzo Bagnardi; Sara Gandini
Journal:  Am J Clin Nutr       Date:  2011-12-14       Impact factor: 7.045

10.  Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.

Authors:  Michael F Holick; Rachael M Biancuzzo; Tai C Chen; Ellen K Klein; Azzie Young; Douglass Bibuld; Richard Reitz; Wael Salameh; Allen Ameri; Andrew D Tannenbaum
Journal:  J Clin Endocrinol Metab       Date:  2007-12-18       Impact factor: 5.958

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  41 in total

1.  Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.

Authors:  Tilman Kühn; Rudolf Kaaks; Birgit Teucher; Frank Hirche; Jutta Dierkes; Cornelia Weikert; Verena Katzke; Heiner Boeing; Gabriele I Stangl; Brian Buijsse
Journal:  Eur J Nutr       Date:  2013-09-05       Impact factor: 5.614

2.  The Differential Role of Vitamin D in Type 2 Diabetes Management and Control in Minority Populations.

Authors:  Miyong To Kim; Kim Byeng Kim; Jisook Ko; Nicole Murry; David Levine; Ju-Young Lee
Journal:  J Immigr Minor Health       Date:  2019-12

3.  Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.

Authors:  Mathilde Touvier; Mélanie Deschasaux; Marion Montourcy; Angela Sutton; Nathalie Charnaux; Emmanuelle Kesse-Guyot; Karen E Assmann; Léopold Fezeu; Paule Latino-Martel; Nathalie Druesne-Pecollo; Christiane Guinot; Julie Latreille; Denis Malvy; Pilar Galan; Serge Hercberg; Sigrid Le Clerc; Jean-Claude Souberbielle; Khaled Ezzedine
Journal:  J Invest Dermatol       Date:  2014-09-11       Impact factor: 8.551

4.  Vitamin D supplementation in nursing home patients: randomized controlled trial of standard daily dose versus individualized loading dose regimen.

Authors:  Hugo Wijnen; Dayenne Salemink; Lian Roovers; Diana Taekema; Hans de Boer
Journal:  Drugs Aging       Date:  2015-05       Impact factor: 3.923

Review 5.  Vitamin D and cardiovascular disease prevention.

Authors:  Stefan Pilz; Nicolas Verheyen; Martin R Grübler; Andreas Tomaschitz; Winfried März
Journal:  Nat Rev Cardiol       Date:  2016-05-06       Impact factor: 32.419

Review 6.  Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.

Authors:  Martin Robert Grübler; Winfried März; Stefan Pilz; Tanja B Grammer; Christian Trummer; Christian Müllner; Verena Schwetz; Marlene Pandis; Nicolas Verheyen; Andreas Tomaschitz; Antonella Fiordelisi; Daniela Laudisio; Ersilia Cipolletta; Guido Iaccarino
Journal:  Rev Endocr Metab Disord       Date:  2017-06       Impact factor: 6.514

7.  Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study.

Authors:  Yanchao Tang; Feng Wei; Miao Yu; Hua Zhou; Yongqiang Wang; Zhiyong Cui; Xiaoguang Liu
Journal:  Sci Rep       Date:  2022-06-21       Impact factor: 4.996

8.  Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults.

Authors:  Sophie Pilleron; Daniela Weber; Karine Pérès; Marco Colpo; David Gomez-Cabrero; Wolfgang Stuetz; Jean-François Dartigues; Luigi Ferrucci; Stefania Bandinelli; Francisco Jose Garcia-Garcia; Tilman Grune; Catherine Féart
Journal:  Eur J Nutr       Date:  2018-01-27       Impact factor: 5.614

Review 9.  Vitamin D supplementation: when and how?

Authors:  Elisabetta Romagnoli; Vincenzo Carnevale; Piergianni Biondi; Salvatore Minisola
Journal:  J Endocrinol Invest       Date:  2014-04-03       Impact factor: 4.256

Review 10.  Dietary supplements and disease prevention - a global overview.

Authors:  Susanne Rautiainen; JoAnn E Manson; Alice H Lichtenstein; Howard D Sesso
Journal:  Nat Rev Endocrinol       Date:  2016-05-06       Impact factor: 43.330

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