Literature DB >> 23224093

Rapid hepatitis C virus divergence among chronically infected individuals.

Mayra Cruz-Rivera1, Juan Carlos Carpio-Pedroza, Alejandro Escobar-Gutiérrez, Daniela Lozano, Arely Vergara-Castaneda, Pilar Rivera-Osorio, Armando Martinez-Guarneros, Carlos A Vazquez Chacon, Salvador Fonseca-Coronado, Gilberto Vaughan.   

Abstract

Here, we analyze the viral divergence among hepatitis C virus (HCV) chronic cases infected with genotype 1. The intrahost viral evolution was assessed by deep sequencing using the 454 Genome Sequencer platform. The results showed a rapid nucleotide sequence divergence. This notorious short-term viral evolution is of the utmost importance for the study of HCV transmission, because direct links between related samples were virtually lost. Thus, rapid divergence of HCV significantly affects genetic relatedness studies and outbreak investigations.

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Year:  2012        PMID： 23224093      PMCID： PMC3553878          DOI： 10.1128/JCM.03042-12

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  29 in total

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Journal:  Nature       Date:  2009-08-16       Impact factor: 49.962

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2.  Vertical transmission of hepatitis C virus: a tale of multiple outcomes.

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Journal:  Viruses       Date:  2015-03-13       Impact factor: 5.048

5.  Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment.

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6.  Spouse-to-Spouse Transmission and Evolution of Hypervariable Region 1 and 5' Untranslated Region of Hepatitis C Virus Analyzed by Next-Generation Sequencing.

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7.  A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro.

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8.  Hepatitis C virus genotype/subtype distribution and evolution among Chinese blood donors: Revealing recent viral expansion.

Authors:  Yu Zhang; Zhan Gao; Shaoli Wang; Jing Liu; Ness Paul; Tao He; Cunxu Liu; Hongbin Zhang; Yunlai Lv; Ru'an Cao; Wei Mao; Jianhua Wan; Hongli Ma; Mei Huang; Yu Liu; Jingxing Wang; Pu Liao; Peibin Zeng; Miao He; Hua Shan
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Review 9.  The role of HCV proteins on treatment outcomes.

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  9 in total

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