OBJECTIVE: The presence of cardiovascular comorbidity in non-small-cell lung cancer (NSCLC) patients increases with age. Therefore, the influence of cardiovascular comorbidity in NSCLC patients on their short- or long-term prognosis remains controversial. This study evaluated the possible risk factors related to the short-term and long-term survivals in NSCLC patients with cardiovascular comorbidity. METHODS: One thousand one hundred and sixty-two consecutive patients with NSCLC who had undergone a surgical resection between 1984 and 2010 were enrolled in this study. A total of 360 (31%) patients with cardiovascular comorbidities were analysed to identify the risk factors for postoperative complications and prognostic factors. RESULTS: The patients with cardiovascular comorbidity included 301 with hypertension, 28 with coronary artery disease, 35 with peripheral vascular disease, 23 with arrhythmia and 11 with abdominal aortic aneurysm. Eighty-three patients exhibited more than one type of comorbidity. The postoperative cardiovascular morbidity rates were 3.6% in the cardiovascular comorbidity patients and 3.3% among patients without cardiovascular comorbidity (P = 0.73). No correlation was observed between preoperative cardiovascular comorbidity and postoperative pulmonary complications (P = 0.52). The operative mortality rates were 1.0% for the cardiovascular comorbidity patients and 0.8% for the other patients (P = 0.51). No difference in the postoperative outcomes was observed between the patients with and without cardiovascular comorbidity. The 5-year survival rates were 62.5% in comparison with 65.4% among patients without cardiovascular comorbidity (P = 0.48). CONCLUSIONS: Patients with cardiovascular comorbidity were not found to be at increased risk of mortality and morbidity following surgery for NSCLC. In addition, cardiovascular comorbidity did not influence the long-term outcomes of patients after a pulmonary resection for NSCLC.
OBJECTIVE: The presence of cardiovascular comorbidity in non-small-cell lung cancer (NSCLC) patients increases with age. Therefore, the influence of cardiovascular comorbidity in NSCLCpatients on their short- or long-term prognosis remains controversial. This study evaluated the possible risk factors related to the short-term and long-term survivals in NSCLCpatients with cardiovascular comorbidity. METHODS: One thousand one hundred and sixty-two consecutive patients with NSCLC who had undergone a surgical resection between 1984 and 2010 were enrolled in this study. A total of 360 (31%) patients with cardiovascular comorbidities were analysed to identify the risk factors for postoperative complications and prognostic factors. RESULTS: The patients with cardiovascular comorbidity included 301 with hypertension, 28 with coronary artery disease, 35 with peripheral vascular disease, 23 with arrhythmia and 11 with abdominal aortic aneurysm. Eighty-three patients exhibited more than one type of comorbidity. The postoperative cardiovascular morbidity rates were 3.6% in the cardiovascular comorbidity patients and 3.3% among patients without cardiovascular comorbidity (P = 0.73). No correlation was observed between preoperative cardiovascular comorbidity and postoperative pulmonary complications (P = 0.52). The operative mortality rates were 1.0% for the cardiovascular comorbidity patients and 0.8% for the other patients (P = 0.51). No difference in the postoperative outcomes was observed between the patients with and without cardiovascular comorbidity. The 5-year survival rates were 62.5% in comparison with 65.4% among patients without cardiovascular comorbidity (P = 0.48). CONCLUSIONS:Patients with cardiovascular comorbidity were not found to be at increased risk of mortality and morbidity following surgery for NSCLC. In addition, cardiovascular comorbidity did not influence the long-term outcomes of patients after a pulmonary resection for NSCLC.
Authors: Natasha M Rueth; Helen M Parsons; Elizabeth B Habermann; Shawn S Groth; Beth A Virnig; Todd M Tuttle; Rafael S Andrade; Michael A Maddaus; Jonathan D'Cunha Journal: J Thorac Cardiovasc Surg Date: 2012-02-15 Impact factor: 5.209
Authors: D Moro-Sibilot; A Aubert; S Diab; S Lantuejoul; P Fourneret; E Brambilla; C Brambilla; P Y Brichon Journal: Eur Respir J Date: 2005-09 Impact factor: 16.671
Authors: M Licker; M de Perrot; L Höhn; J M Tschopp; J Robert; J G Frey; A Schweizer; A Spiliopoulos Journal: Eur J Cardiothorac Surg Date: 1999-03 Impact factor: 4.191
Authors: M L G Janssen-Heijnen; S Smulders; V E P P Lemmens; F W J M Smeenk; H J A A van Geffen; J W W Coebergh Journal: Thorax Date: 2004-07 Impact factor: 9.139
Authors: Daniel J Boffa; Mark S Allen; Joshua D Grab; Henning A Gaissert; David H Harpole; Cameron D Wright Journal: J Thorac Cardiovasc Surg Date: 2007-12-21 Impact factor: 5.209
Authors: Marc Licker; Anastase Spiliopoulos; Jean-Georges Frey; John Robert; Laurent Höhn; Marc de Perrot; Jean-Marie Tschopp Journal: Chest Date: 2002-06 Impact factor: 9.410
Authors: Eeva Haapio; T Kiviniemi; H Irjala; P Koivunen; J K E Airaksinen; I Kinnunen Journal: Eur Arch Otorhinolaryngol Date: 2016-07-04 Impact factor: 2.503
Authors: Hannes Halldorsson; Andri Wilberg Orrason; Gudrun Nina Oskarsdottir; Astridur Petursdottir; Bjorn Mar Fridriksson; Magnus Karl Magnusson; Steinn Jonsson; Tomas Gudbjartsson Journal: Ann Transl Med Date: 2019-03