Literature DB >> 23220236

The novel allele (3R) of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression.

Mehrdad Rajaei1, Iraj Saadat, Mostafa Saadat.   

Abstract

Polymorphism of variable number of tandem repeats (VNTR) in the promoter region of X-ray repair cross-complementing 5 (MIM: 194364, XRCC5; rs6147172) was reported. The aim of the present study is to evaluate the influence of this polymorphism on XRCC5 mRNA levels. Genotypes of XRCC5 VNTR were determined by high resolution of melting analysis (HRMA). The quantitative XRCC5 mRNA expression (compared to ß-actin expression) among 0R/1R, 1R/2R, and 1R/3R genotypes was investigated. There was a negative correlation between the overall number of tandem repeats and XRCC5 expression (r=-0.965, df=7, P<0.001). The mRNA level of XRCC5 decreased as function of number of tandem repeats. The 3R allele of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 23220236     DOI： 10.1016/j.bbrc.2012.11.099

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer.

Authors:  Mehrdad Rajaei; Iraj Saadat; Shahpour Omidvari; Mostafa Saadat
Journal:  Med Oncol       Date:  2014-03-11       Impact factor: 3.064

2.  Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5.

Authors:  Mostafa Saadat; Samira Pashaei; Foroozan Amerizade
Journal:  Pathol Oncol Res       Date:  2014-12-20       Impact factor: 3.201

3.  Association of XRCC5 VNTR polymorphism with the development of chronic myeloid leukemia.

Authors:  Manjula Gorre; Prajitha Edathara Mohandas; Sailaja Kagita; Sandhya Annamaneni; Raghunadharao Digumarti; Vishnupriya Satti
Journal:  Tumour Biol       Date:  2013-08-28

4.  Genetic association of XRCC5 gene polymorphisms with breast cancer among Jordanian women.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Mansour A Alghamdi; Rame H Khasawneh
Journal:  Onco Targets Ther       Date:  2019-09-26       Impact factor: 4.147

5.  XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies.

Authors:  Danial Jahantigh; Abasalt Hosseinzadeh Colagar
Journal:  Int J Endocrinol       Date:  2017-03-21       Impact factor: 3.257

6.  Differences of Variable Number Tandem Repeats in XRCC5 Promoter Are Associated with Increased or Decreased Risk of Breast Cancer in BRCA Gene Mutation Carriers.

Authors:  Jian Cui; Jiangtao Luo; Yeong C Kim; Carrie Snyder; Dina Becirovic; Bradley Downs; Henry Lynch; San Ming Wang
Journal:  Front Oncol       Date:  2016-04-13       Impact factor: 6.244
  6 in total

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