OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) may be a risk factor for dementia development in patients with Parkinson's disease (PD); however, the role of subclinical RBD remains unknown. Patients with PD and clinical RBD, subclinical RBD, or with normal REM sleep were examined in a cross sectional study and a longitudinal follow-up. METHODS: Interviews regarding RBD symptoms and polysomnographies were performed on 82 PD patients divided into RBD subcategories based on the presence/absence of REM sleep without atonia (RWA) and/or RBD symptoms. Descriptive variables were compared and patients were followed-up longitudinally for 21.4±10.8months. RESULTS: The existence of RBD, but not subclinical RBD, was associated with orthostatic hypotension and levodopa dose equivalents (LDEs) in patients with PD. Kaplan-Myer curves indicated that the occurrence of dementia in the PD group with clinical RBD was significantly faster than in the PD group with normal REM sleep (p=0.013). A Cox hazard regression analysis revealed that development to PD with dementia was only significantly associated with the presence of clinical RBD (hazard ratio: 14.1, p=0.017). CONCLUSION: Clinical RBD symptoms, but not subclinical RBD, were associated with the development of dementia in PD.
OBJECTIVE:Rapid eye movement (REM) sleep behavior disorder (RBD) may be a risk factor for dementia development in patients with Parkinson's disease (PD); however, the role of subclinical RBD remains unknown. Patients with PD and clinical RBD, subclinical RBD, or with normal REM sleep were examined in a cross sectional study and a longitudinal follow-up. METHODS: Interviews regarding RBD symptoms and polysomnographies were performed on 82 PDpatients divided into RBD subcategories based on the presence/absence of REM sleep without atonia (RWA) and/or RBD symptoms. Descriptive variables were compared and patients were followed-up longitudinally for 21.4±10.8months. RESULTS: The existence of RBD, but not subclinical RBD, was associated with orthostatic hypotension and levodopa dose equivalents (LDEs) in patients with PD. Kaplan-Myer curves indicated that the occurrence of dementia in the PD group with clinical RBD was significantly faster than in the PD group with normal REM sleep (p=0.013). A Cox hazard regression analysis revealed that development to PD with dementia was only significantly associated with the presence of clinical RBD (hazard ratio: 14.1, p=0.017). CONCLUSION: Clinical RBD symptoms, but not subclinical RBD, were associated with the development of dementia in PD.
Authors: Luigi Ferini-Strambi; Wolfgang Oertel; Yves Dauvilliers; Ronald B Postuma; Sara Marelli; Alex Iranzo; Isabelle Arnulf; Birgit Högl; Högl Birgit; Raffaele Manni; Tomoyuki Miyamoto; Maria-Livia Fantini; Monica Puligheddu; Poul Jennum; Karel Sonka; Joan Santamaria; Marco Zucconi; Paola M V Rancoita; Smeranda Leu-Semenescu; Birgit Frauscher; Michele Terzaghi; Masayuki Miyamoto; Marcus Unger; Karin Stiasny-Kolster; Alex Desautels; Christina Wolfson; Amélie Pelletier; Jacques Montplaisir Journal: J Neurol Date: 2014-04-01 Impact factor: 4.849
Authors: Shady Rahayel; Malo Gaubert; Ronald B Postuma; Jacques Montplaisir; Julie Carrier; Oury Monchi; David Rémillard-Pelchat; Pierre-Alexandre Bourgouin; Michel Panisset; Sylvain Chouinard; Sven Joubert; Jean-François Gagnon Journal: Sleep Date: 2019-06-11 Impact factor: 5.849
Authors: Ronald B Postuma; Alex Iranzo; Birgit Hogl; Isabelle Arnulf; Luigi Ferini-Strambi; Raffaele Manni; Tomoyuki Miyamoto; Wolfgang Oertel; Yves Dauvilliers; Yo-El Ju; Monica Puligheddu; Karel Sonka; Amelie Pelletier; Juan Santamaria; Birgit Frauscher; Smaranda Leu-Semenescu; Marco Zucconi; Michele Terzaghi; Masayuki Miyamoto; Marcus M Unger; Bertrand Carlander; Maria-Livia Fantini; Jacques Y Montplaisir Journal: Ann Neurol Date: 2015-03-13 Impact factor: 10.422
Authors: Julius B M Anang; Jean-Francois Gagnon; Josie-Anne Bertrand; Silvia Rios Romenets; Veronique Latreille; Michel Panisset; Jacques Montplaisir; Ronald B Postuma Journal: Neurology Date: 2014-08-29 Impact factor: 9.910