| Literature DB >> 23218378 |
Zhen-Yuan Zhu1, Yang Liu, Chuan-Ling Si, Jing Yuan, Qiang Lv, Yuan-Yuan Li, Guo-Ling Dong, An-Jun Liu, Yong-Min Zhang.
Abstract
A chemically new sulfated polysaccharide (SPS50) was prepared from the water soluble polysaccharide (PS50), isolated from Cordyceps_gunnii mycelia, by concentrated sulfuric acid method. The yield of crude SPS50 was 62.34% and its specific rotation was [α](D)(20)=-36.75°. The structural characteristics of this chemically sulfated polysaccharide were determined based on the infrared analysis (IR), high performance liquid chromatography (HPLC) and sodium dodecyl sulfate polyacrylamide gel electropheresis (SDS-PAGE). Its biological properties including anti-oxidant and anti-tumor activities were also investigated. The results showed that the anti-oxidant capacity of SPS50 was not as good as SP50 and the anti-tumor activity of SPS50 was much better than PS50. SPS50 showed evident growth inhibition on K562 cells. The tumor inhibition ratio of SPS50 against K562 cells was 69.92%.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23218378 DOI： 10.1016/j.carbpol.2012.10.007
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381