OBJECTIVES: A binary system is reputed to be superior to the World Health Organization (WHO) system in grading oral dysplasia. We aimed to validate its reproducibility and prognostic ability and examine whether it could be improved. STUDY DESIGN: Three pathologists graded 141 oral epithelial dysplasia biopsies with the use of both systems. Observer variability and prognostic ability were assessed with the use of kappa and logistic regression models. RESULTS: The binary system showed superior agreement to the WHO system (multirater kappa 0.59 vs. 0.49, respectively) but similar prognostic ability (odds ratio [OR] 4.59 [P = .014] vs. OR 2.25 [P = .02], respectively). Adding smoking and alcohol slightly improved the prognostic ability of both systems (OR 5.10 vs. OR 2.42, respectively). Our new binary system with a refined diagnostic threshold demonstrated a slightly greater prognostic ability and improved ability to differentiate between high- and low-risk moderate dysplasia cases. CONCLUSIONS: The binary system has similar prognostic ability but superior reproducibility compared with the WHO system. Prognostication is improved still further by using a new threshold.
OBJECTIVES: A binary system is reputed to be superior to the World Health Organization (WHO) system in grading oral dysplasia. We aimed to validate its reproducibility and prognostic ability and examine whether it could be improved. STUDY DESIGN: Three pathologists graded 141 oral epithelial dysplasia biopsies with the use of both systems. Observer variability and prognostic ability were assessed with the use of kappa and logistic regression models. RESULTS: The binary system showed superior agreement to the WHO system (multirater kappa 0.59 vs. 0.49, respectively) but similar prognostic ability (odds ratio [OR] 4.59 [P = .014] vs. OR 2.25 [P = .02], respectively). Adding smoking and alcohol slightly improved the prognostic ability of both systems (OR 5.10 vs. OR 2.42, respectively). Our new binary system with a refined diagnostic threshold demonstrated a slightly greater prognostic ability and improved ability to differentiate between high- and low-risk moderate dysplasia cases. CONCLUSIONS: The binary system has similar prognostic ability but superior reproducibility compared with the WHO system. Prognostication is improved still further by using a new threshold.
Authors: Katelin D Cherry; Richard A Schwarz; Eric C Yang; Imran S Vohra; Hawraa Badaoui; Michelle D Williams; Nadarajah Vigneswaran; Ann M Gillenwater; Rebecca Richards-Kortum Journal: Cancer Prev Res (Phila) Date: 2019-08-26
Authors: Thamiris de Castro Abrantes; Thamyres Campos Fonsêca; Márcia Grillo Cabral; Michelle Agostini; Bruno Augusto Benevenuto de Andrade; Mário José Romañach; Aline Corrêa Abrahão Journal: Head Neck Pathol Date: 2020-12-28
Authors: Brunno Santos de Freitas Silva; Danielle Coelho Ribeiro Batista; Camila Ferro de Souza Roriz; Lorena Rosa Silva; Ana Gabriela Costa Normando; Alan Roger Dos Santos Silva; Maria Alves Garcia Silva; Fernanda Paula Yamamoto-Silva Journal: Clin Oral Investig Date: 2021-05-29 Impact factor: 3.573
Authors: Joseph Solomon; Ashley Hinther; T Wayne Matthews; Steven C Nakoneshny; Rob Hart; Joseph C Dort; Shamir P Chandarana Journal: J Otolaryngol Head Neck Surg Date: 2021-02-12
Authors: Craig Murdoch; Brian H Brown; Vanessa Hearnden; Paul M Speight; Katy D'Apice; Anne M Hegarty; John A Tidy; T Jamie Healey; Peter E Highfield; Martin H Thornhill Journal: Int J Nanomedicine Date: 2014-09-23