OBJECTIVE: The aim of this study was to assess microorganisms associated with vascular access-associated infections (VAIs) in hemodialysis patients, with respect to possible origin from the mouth. STUDY DESIGN: A retrospective and comparative analysis of the microbes associated with VAI in hemodialysis patients treated during a 10-year period was performed with the Human Oral Microbiome Database (HOMD). RESULTS: Of 218 patient records identified, 65 patients collectively experienced 115 VAI episodes. The most common microorganisms involved were Staphylococcus aureus (49.6% of infections), Staphylococcus epidermidis (10.4%), Serratia marcescens (10.4%), Pseudomonas aeruginosa (9.6%), and Enterococcus faecalis/fecum (8.7%). None of these was found in ≥1% of HOMD clone libraries, indicating that they very rarely colonize the teeth or plaque. CONCLUSIONS: Most VAIs were associated with microorganisms more likely to originate from other body sites than from the oral cavity. The risk of a VAI being caused by microorganisms originating from the oral cavity is very small.
OBJECTIVE: The aim of this study was to assess microorganisms associated with vascular access-associatedinfections (VAIs) in hemodialysis patients, with respect to possible origin from the mouth. STUDY DESIGN: A retrospective and comparative analysis of the microbes associated with VAI in hemodialysis patients treated during a 10-year period was performed with the Human Oral Microbiome Database (HOMD). RESULTS: Of 218 patient records identified, 65 patients collectively experienced 115 VAI episodes. The most common microorganisms involved were Staphylococcus aureus (49.6% of infections), Staphylococcus epidermidis (10.4%), Serratia marcescens (10.4%), Pseudomonas aeruginosa (9.6%), and Enterococcus faecalis/fecum (8.7%). None of these was found in ≥1% of HOMD clone libraries, indicating that they very rarely colonize the teeth or plaque. CONCLUSIONS: Most VAIs were associated with microorganisms more likely to originate from other body sites than from the oral cavity. The risk of a VAI being caused by microorganisms originating from the oral cavity is very small.
Authors: Peter B Lockhart; Michael T Brennan; Philip C Fox; H James Norton; Daniel B Jernigan; Larry J Strausbaugh Journal: Clin Infect Dis Date: 2002-05-23 Impact factor: 9.079
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Authors: Farah K Bahrani-Mougeot; Bruce J Paster; Shirley Coleman; Jignya Ashar; Sue Knost; Robert L Sautter; Peter B Lockhart Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2008-06
Authors: G B Zibari; M F Gadallah; M Landreneau; R McMillan; R M Bridges; K Costley; J Work; J C McDonald Journal: Am J Kidney Dis Date: 1997-09 Impact factor: 8.860
Authors: Galib Shariff; Michael T Brennan; M Louise Kent; Philip C Fox; David Weinrib; Patrick Burgess; Peter B Lockhart Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2004-10
Authors: Mahmoud A Ghannoum; Richard J Jurevic; Pranab K Mukherjee; Fan Cui; Masoumeh Sikaroodi; Ammar Naqvi; Patrick M Gillevet Journal: PLoS Pathog Date: 2010-01-08 Impact factor: 6.823