AIM: This study was aimed at developing a pharmacogenetic-driven warfarin-dosing algorithm in 163 admixed Puerto Rican patients on stable warfarin therapy. PATIENTS & METHODS: A multiple linear-regression analysis was performed using log-transformed effective warfarin dose as the dependent variable, and combining CYP2C9 and VKORC1 genotyping with other relevant nongenetic clinical and demographic factors as independent predictors. RESULTS: The model explained more than two-thirds of the observed variance in the warfarin dose among Puerto Ricans, and also produced significantly better 'ideal dose' estimates than two pharmacogenetic models and clinical algorithms published previously, with the greatest benefit seen in patients ultimately requiring <7 mg/day. We also assessed the clinical validity of the model using an independent validation cohort of 55 Puerto Rican patients from Hartford, CT, USA (R(2) = 51%). CONCLUSION: Our findings provide the basis for planning prospective pharmacogenetic studies to demonstrate the clinical utility of genotyping warfarin-treated Puerto Rican patients.
AIM: This study was aimed at developing a pharmacogenetic-driven warfarin-dosing algorithm in 163 admixed Puerto Rican patients on stable warfarin therapy. PATIENTS & METHODS: A multiple linear-regression analysis was performed using log-transformed effective warfarin dose as the dependent variable, and combining CYP2C9 and VKORC1 genotyping with other relevant nongenetic clinical and demographic factors as independent predictors. RESULTS: The model explained more than two-thirds of the observed variance in the warfarin dose among Puerto Ricans, and also produced significantly better 'ideal dose' estimates than two pharmacogenetic models and clinical algorithms published previously, with the greatest benefit seen in patients ultimately requiring <7 mg/day. We also assessed the clinical validity of the model using an independent validation cohort of 55 Puerto Rican patients from Hartford, CT, USA (R(2) = 51%). CONCLUSION: Our findings provide the basis for planning prospective pharmacogenetic studies to demonstrate the clinical utility of genotyping warfarin-treated Puerto Rican patients.
Authors: David L Veenstra; Joyce H S You; Mark J Rieder; Federico M Farin; Hui-Wen Wilkerson; David K Blough; Gregory Cheng; Allan E Rettie Journal: Pharmacogenet Genomics Date: 2005-10 Impact factor: 2.089
Authors: M Wadelius; L Y Chen; K Downes; J Ghori; S Hunt; N Eriksson; O Wallerman; H Melhus; C Wadelius; D Bentley; P Deloukas Journal: Pharmacogenomics J Date: 2005 Impact factor: 3.550
Authors: Mark J Rieder; Alexander P Reiner; Brian F Gage; Deborah A Nickerson; Charles S Eby; Howard L McLeod; David K Blough; Kenneth E Thummel; David L Veenstra; Allan E Rettie Journal: N Engl J Med Date: 2005-06-02 Impact factor: 91.245
Authors: Elizabeth A Sconce; Tayyaba I Khan; Hilary A Wynne; Peter Avery; Louise Monkhouse; Barry P King; Peter Wood; Patrick Kesteven; Ann K Daly; Farhad Kamali Journal: Blood Date: 2005-06-09 Impact factor: 22.113
Authors: Shweta Choudhry; Ngim Ung; Pedro C Avila; Elad Ziv; Sylvette Nazario; Jesus Casal; Alfonso Torres; Jennifer D Gorman; Keyan Salari; Jose R Rodriguez-Santana; Monica Toscano; Jody Senter Sylvia; MariaElena Alioto; Richard A Castro; Michael Salazar; Ivan Gomez; Joanne K Fagan; Jorge Salas; Suzanne Clark; Craig Lilly; Henry Matallana; Moises Selman; Rocio Chapela; Dean Sheppard; Scott T Weiss; Jean G Ford; Homer A Boushey; Jeffrey M Drazen; William Rodriguez-Cintron; Edwin K Silverman; Esteban González Burchard Journal: Am J Respir Crit Care Med Date: 2004-11-19 Impact factor: 21.405
Authors: Simone Rost; Andreas Fregin; Vytautas Ivaskevicius; Ernst Conzelmann; Konstanze Hörtnagel; Hans-Joachim Pelz; Knut Lappegard; Erhard Seifried; Inge Scharrer; Edward G D Tuddenham; Clemens R Müller; Tim M Strom; Johannes Oldenburg Journal: Nature Date: 2004-02-05 Impact factor: 49.962
Authors: Michael A Hillman; Russell A Wilke; Michael D Caldwell; Richard L Berg; Ingrid Glurich; James K Burmester Journal: Pharmacogenetics Date: 2004-08
Authors: Carolina Céspedes-Garro; María-Eugenia G Naranjo; Fernanda Rodrigues-Soares; Adrián LLerena; Jorge Duconge; Lazara K Montané-Jaime; Hilda Roblejo; Humberto Fariñas; María de Los A Campos; Ronald Ramírez; Víctor Serrano; Carmen I Villagrán; Eva M Peñas-LLedó Journal: Pharmacogenomics Date: 2016-09-16 Impact factor: 2.533
Authors: Talitha I Verhoef; William K Redekop; Ann K Daly; Rianne M F van Schie; Anthonius de Boer; Anke-Hilse Maitland-van der Zee Journal: Br J Clin Pharmacol Date: 2014-04 Impact factor: 4.335
Authors: Innocent G Asiimwe; Eunice J Zhang; Rostam Osanlou; Amanda Krause; Chrisly Dillon; Guilherme Suarez-Kurtz; Honghong Zhang; Jamila A Perini; Jessicca Y Renta; Jorge Duconge; Larisa H Cavallari; Leiliane R Marcatto; Mark T Beasly; Minoli A Perera; Nita A Limdi; Paulo C J L Santos; Stephen E Kimmel; Steven A Lubitz; Stuart A Scott; Vivian K Kawai; Andrea L Jorgensen; Munir Pirmohamed Journal: Clin Pharmacol Ther Date: 2020-01-28 Impact factor: 6.875
Authors: Justin B Kaye; Lauren E Schultz; Heidi E Steiner; Rick A Kittles; Larisa H Cavallari; Jason H Karnes Journal: Pharmacotherapy Date: 2017-09-06 Impact factor: 4.705
Authors: Li Zhao; Chunxia Chen; Bei Li; Li Dong; Yingqiang Guo; Xijun Xiao; Eryong Zhang; Li Qin Journal: PLoS One Date: 2014-04-11 Impact factor: 3.240