Literature DB >> 23207649

Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis.

N Toepfner1, P Henneke, R Berner, M Hufnagel.   

Abstract

Rapid antigen detection tests (RADT) are widely used for the rapid diagnosis of group A streptococcal (GAS) tonsillopharyngitis. In a prospective 3-year study, the reliability of two different RADT methods was compared, as performed by lab technicians versus physicians. Sensitivity and specificity, as well as positive and negative predictive values, were calculated. When performed by physicians, the results (44.4 %, 8.3 %, 26.7 % and 16.7 %) of a latex agglutination test (LAT) were unacceptably low. However, after switching to a lateral-flow immunoassay (LFIT) and implementing additional hands-on training, the performance improved dramatically (100 %, 92.6 %, 84.6 % and 100 %). In conclusion, technical errors, along with a lack of experience and expertise, negatively impact RADT accuracy.

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Year:  2012        PMID： 23207649     DOI： 10.1007/s10096-012-1783-7

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  6 in total

1.  Sensitivity and specificity of rapid antigen detection testing for diagnosing pharyngitis in the emergency department.

Authors:  Sezgin Sarikaya; Can Aktaş; Didem Ay; Asli Cetin; Ferudun Celikmen
Journal:  Ear Nose Throat J       Date:  2010-04       Impact factor: 1.697

2.  [Early diagnosis of streptococcal pharyngitis in paediatric practice: Validity of a rapid antigen detection test].

Authors:  Gemma Flores Mateo; Jaume Conejero; Elisabet Grenzner Martinel; Zeki Baba; Susana Dicono; Mildrey Echasabal; Concepción Gonzalo Santos; Arantxa Aliaga; María Barredo; Luis Ruiz; Montserrat Carrau
Journal:  Aten Primaria       Date:  2010-03-26       Impact factor: 1.137

Review 3.  [Evaluation of rapid methods for detecting Streptococcus pyogenes. Systematic review and meta-analysis].

Authors:  J Ruiz-Aragón; R Rodríguez López; J M Molina Linde
Journal:  An Pediatr (Barc)       Date:  2010-03-25       Impact factor: 1.500

4.  Impact of rapid antigen detection testing on antibiotic prescription in acute pharyngitis in adults. FARINGOCAT STUDY: a multicentric randomized controlled trial.

Authors:  Jordi Madurell; Montse Balagué; Mónica Gómez; Josep M Cots; Carl Llor
Journal:  BMC Fam Pract       Date:  2010-03-23       Impact factor: 2.497

5.  Burden and economic cost of group A streptococcal pharyngitis.

Authors:  Elizabeth Pfoh; Michael R Wessels; Donald Goldmann; Grace M Lee
Journal:  Pediatrics       Date:  2008-02       Impact factor: 7.124

Review 6.  Group A streptococcal pharyngitis and immune-mediated complications: from diagnosis to management.

Authors:  Stanford T Shulman; Robert R Tanz
Journal:  Expert Rev Anti Infect Ther       Date:  2010-02       Impact factor: 5.091
  6 in total
  7 in total

1.  Comparison of the BD Veritor System for Flu A+B with the Alere BinaxNOW influenza A&B card for detection of influenza A and B viruses in respiratory specimens from pediatric patients.

Authors:  Ferdaus Hassan; Ashley Nguyen; Ashley Formanek; James J Bell; Rangaraj Selvarangan
Journal:  J Clin Microbiol       Date:  2014-01-03       Impact factor: 5.948

2.  Reassessment of the Role of Rapid Antigen Detection Tests in Diagnosis of Invasive Group A Streptococcal Infections.

Authors:  Vincent Gazzano; Anne Berger; Yvonne Benito; Anne-Marie Freydiere; Anne Tristan; Sandrine Boisset; Anne Carricajo; Claire Poyart; François Vandenesch; Ghislaine Descours
Journal:  J Clin Microbiol       Date:  2016-01-27       Impact factor: 5.948

Review 3.  Rapid antigen detection test for group A streptococcus in children with pharyngitis.

Authors:  Jérémie F Cohen; Nathalie Bertille; Robert Cohen; Martin Chalumeau
Journal:  Cochrane Database Syst Rev       Date:  2016-07-04

Review 4.  Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis.

Authors:  Emily H Stewart; Brian Davis; B Lee Clemans-Taylor; Benjamin Littenberg; Carlos A Estrada; Robert M Centor
Journal:  PLoS One       Date:  2014-11-04       Impact factor: 3.240

5.  Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.

Authors:  Jochen P Windfuhr; Nicole Toepfner; Gregor Steffen; Frank Waldfahrer; Reinhard Berner
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-01-11       Impact factor: 2.503

6.  [Recommendations for the use of rapid diagnosis techniques in respiratory infections in primary care].

Authors:  Carles Llor; Miriam Alkorta Gurrutxaga; Josep de la Flor I Bru; Sílvia Bernárdez Carracedo; José Luis Cañada Merino; Mario Bárcena Caamaño; Carmen Serrano Martino; Josep Maria Cots Yago
Journal:  Aten Primaria       Date:  2017-06-13       Impact factor: 1.137

Review 7.  Recent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum.

Authors:  Joselyn Rwebembera; Bruno Ramos Nascimento; Neema W Minja; Sarah de Loizaga; Twalib Aliku; Luiza Pereira Afonso Dos Santos; Bruno Fernandes Galdino; Luiza Silame Corte; Vicente Rezende Silva; Andrew Young Chang; Walderez Ornelas Dutra; Maria Carmo Pereira Nunes; Andrea Zawacki Beaton
Journal:  Pathogens       Date:  2022-01-28
  7 in total

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