PURPOSE: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. MATERIALS AND METHODS: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. RESULTS: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p <0.001). The index offered improved discrimination of prostate cancer detection on biopsy (AUC 0.704) compared to percent free or total prostate specific antigen using the WHO calibration. CONCLUSIONS: The Prostate Health Index can be calculated using Hybritech or WHO standardized assays. It significantly improved prediction of the biopsy outcome over that of percent free or prostate specific antigen alone.
PURPOSE: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. MATERIALS AND METHODS:Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. RESULTS: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p <0.001). The index offered improved discrimination of prostate cancer detection on biopsy (AUC 0.704) compared to percent free or total prostate specific antigen using the WHO calibration. CONCLUSIONS: The Prostate Health Index can be calculated using Hybritech or WHO standardized assays. It significantly improved prediction of the biopsy outcome over that of percent free or prostate specific antigen alone.
Authors: Lori J Sokoll; Daniel W Chan; George G Klee; William L Roberts; Ron H N van Schaik; Dorothy A Arockiasamy; Dennis L Broyles; Corey M Carlson; Isaac A Mizrahi; Tina B Pierson; Jeffrey E Tam Journal: Clin Chim Acta Date: 2012-04-20 Impact factor: 3.786
Authors: Carsten Stephan; Moritz Klaas; Christian Müller; Dietmar Schnorr; Stefan A Loening; Klaus Jung Journal: Clin Chem Date: 2006-01 Impact factor: 8.327
Authors: Stacy Loeb; Daniel W Chan; Lori Sokoll; Donghui Kan; Jack Maggiore; Stephen D Mikolajczyk; Dana M Mondo; Chris R Griffin; William J Catalona Journal: J Urol Date: 2008-09-17 Impact factor: 7.450
Authors: W J Catalona; A W Partin; K M Slawin; M K Brawer; R C Flanigan; A Patel; J P Richie; J B deKernion; P C Walsh; P T Scardino; P H Lange; E N Subong; R E Parson; G H Gasior; K G Loveland; P C Southwick Journal: JAMA Date: 1998-05-20 Impact factor: 56.272
Authors: William J Catalona; Alan W Partin; Martin G Sanda; John T Wei; George G Klee; Chris H Bangma; Kevin M Slawin; Leonard S Marks; Stacy Loeb; Dennis L Broyles; Sanghyuk S Shin; Amabelle B Cruz; Daniel W Chan; Lori J Sokoll; William L Roberts; Ron H N van Schaik; Isaac A Mizrahi Journal: J Urol Date: 2011-03-17 Impact factor: 7.450
Authors: W J Catalona; D S Smith; T L Ratliff; K M Dodds; D E Coplen; J J Yuan; J A Petros; G L Andriole Journal: N Engl J Med Date: 1991-04-25 Impact factor: 91.245
Authors: Stephen D Mikolajczyk; William J Catalona; Cindy L Evans; Harry J Linton; Lisa S Millar; Kathy M Marker; Diksha Katir; Anna Amirkhan; Harry G Rittenhouse Journal: Clin Chem Date: 2004-03-30 Impact factor: 8.327
Authors: Marlon Perera; Lewis Smith; Ian Thompson; Geoff Breemer; Nathan Papa; Manish I Patel; Peter Swindle; Elliot Smith Journal: Eur Urol Focus Date: 2021-12-14