Literature DB >> 23200180

Neuropathic tissue responds preferentially to stimulation by intense focused ultrasound.

Rowen E Tych1, Michael Gofeld, Jeffrey G Jarvik, Michel Kliot, John D Loeser, Abbi M McClintic, Ryan J Ollos, Kristin D Pederson, Rachel E Sparks, Gregory W Terman, Pierre D Mourad.   

Abstract

We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm(2) ± 25.5) than did sham surgery (97.7 W/cm(2) ± 11.9) and normal control (> 223 W/cm(2)) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies.
Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23200180      PMCID： PMC3919038          DOI： 10.1016/j.ultrasmedbio.2012.08.012

Source DB:  PubMed          Journal:  Ultrasound Med Biol        ISSN： 0301-5629            Impact factor:   2.998


  15 in total

1.  Soy-containing diet suppresses chronic neuropathic sensory disorders in rats.

Authors:  Y Shir; R Sheth; J N Campbell; S N Raja; Z Seltzer
Journal:  Anesth Analg       Date:  2001-04       Impact factor: 5.108

2.  A study of reception with the use of focused ultrasound. II. Effects on the animal receptor structures.

Authors:  L R Gavrilov; G V Gersuni; O B Ilyinsky; E M Tsirulnikov; E E Shchekanov
Journal:  Brain Res       Date:  1977-10-28       Impact factor: 3.252

3.  Temporal summation of pain from skin, muscle and joint following nociceptive ultrasonic stimulation in humans.

Authors:  A Wright; T Graven-Nielsen; I I Davies; L Arendt-Nielsen
Journal:  Exp Brain Res       Date:  2002-04-23       Impact factor: 1.972

4.  Intense focused ultrasound can reliably induce sensations in human test subjects in a manner correlated with the density of their mechanoreceptors.

Authors:  Trevor C Dickey; Rowen Tych; Michel Kliot; John D Loeser; Kristin Pederson; Pierre D Mourad
Journal:  Ultrasound Med Biol       Date:  2011-11-21       Impact factor: 2.998

5.  Tactile perception of ultrasound.

Authors:  D Dalecki; S Z Child; C H Raeman; E L Carstensen
Journal:  J Acoust Soc Am       Date:  1995-05       Impact factor: 1.840

6.  Lesion development in focused ultrasound surgery: a general model.

Authors:  C R Hill; I Rivens; M G Vaughan; G R ter Haar
Journal:  Ultrasound Med Biol       Date:  1994       Impact factor: 2.998

7.  [Effect of exposure to focused megahertz-range ultrasound on the structure of the otic labyrinth during the process of auditory perception].

Authors:  G V Gershuni; E M Tsirul'nikov; L R Gavrilov; V I Pudov; A S Rozenblium
Journal:  Dokl Akad Nauk SSSR       Date:  1980

8.  A study of reception with the use of focused ultrasound. I. Effects on the skin and deep receptor structures in man.

Authors:  L R Gavrilov; G V Gersuni; O B Ilyinski; E M Tsirulnikov; E E Shchekanov
Journal:  Brain Res       Date:  1977-10-28       Impact factor: 3.252

9.  A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.

Authors:  Ze'ev Seltzer; Ronald Dubner; Yoram Shir
Journal:  Pain       Date:  1990-11       Impact factor: 6.961

Review 10.  Application of focused ultrasound for the stimulation of neural structures.

Authors:  L R Gavrilov; E M Tsirulnikov; I A Davies
Journal:  Ultrasound Med Biol       Date:  1996       Impact factor: 2.998
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Authors:  Abbi M McClintic; Josephine B Garcia; Michael Gofeld; Michel Kliot; John C Kucewicz; John D Loeser; Kristin D Pederson; Rachel E Sparks; Gregory W Terman; Rowen E Tych; Pierre D Mourad
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Authors:  Michael S Bobola; Lucas Chen; Chikodinaka K Ezeokeke; Katy Kuznetsova; Annamarie C Lahti; Weicheng Lou; Aleksey N Myroniv; Nels W Schimek; Madison L Selby; Pierre D Mourad
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Review 7.  Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.

Authors:  Joseph Blackmore; Shamit Shrivastava; Jerome Sallet; Chris R Butler; Robin O Cleveland
Journal:  Ultrasound Med Biol       Date:  2019-05-18       Impact factor: 2.998

Review 8.  Focused Ultrasound (FUS) for Chronic Pain Management: Approved and Potential Applications.

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Journal:  J Ther Ultrasound       Date:  2016-05-20

10.  Therapeutic Potential of Ultrasound Neuromodulation in Decreasing Neuropathic Pain: Clinical and Experimental Evidence.

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  10 in total

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