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Literature DB >> 23200121

Titivated for destruction: the methyl degron.

Abstract

In this issue, Lee et al. (2012) demonstrate that the degradation of RORα is regulated by the EZH2-DCAF1/DDB1/CUL4 proteasome axis, thus identifying protein methylation as a posttranslational modification that can orchestrate protein destruction through a motif termed the "methyl degron."

Entities: CellLine Chemical Disease Gene Species

Year: 2012 PMID： 23200121 PMCID： PMC3563253 DOI： 10.1016/j.molcel.2012.11.007

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

8 in total

1. PRC2 directly methylates GATA4 and represses its transcriptional activity.

Authors: Aibin He; Xiaohua Shen; Qing Ma; Jingjing Cao; Alexander von Gise; Pingzhu Zhou; Gang Wang; Victor E Marquez; Stuart H Orkin; William T Pu
Journal: Genes Dev Date: 2012-01-01 Impact factor: 11.361

2. Naming a targeting signal.

Authors: A Varshavsky
Journal: Cell Date: 1991-01-11 Impact factor: 41.582

3. Methylation, a new epigenetic mark for protein stability.

Authors: Xiao-Dong Yang; Acacia Lamb; Lin-Feng Chen
Journal: Epigenetics Date: 2009-10-10 Impact factor: 4.528

4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

Authors: Leigh Ann Higa; Min Wu; Tao Ye; Ryuji Kobayashi; Hong Sun; Hui Zhang
Journal: Nat Cell Biol Date: 2006-10-15 Impact factor: 28.824

Review 5. Readers of histone modifications.

Authors: Miyong Yun; Jun Wu; Jerry L Workman; Bing Li
Journal: Cell Res Date: 2011-03-22 Impact factor: 25.617

6. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

Authors: Ji Min Lee; Jason S Lee; Hyunkyung Kim; Kyeongkyu Kim; Hyejin Park; Ji-Young Kim; Seung Hoon Lee; Ik Soo Kim; Joomyung Kim; Minkyoung Lee; Chin Ha Chung; Sang-Beom Seo; Jong-Bok Yoon; Eunyoung Ko; Dong-Young Noh; Keun Il Kim; Kyeong Kyu Kim; Sung Hee Baek
Journal: Mol Cell Date: 2012-10-11 Impact factor: 17.970

Review 7. Diversity of degradation signals in the ubiquitin-proteasome system.

Authors: Tommer Ravid; Mark Hochstrasser
Journal: Nat Rev Mol Cell Biol Date: 2008-09 Impact factor: 94.444

Review 8. The role of EZH2 in tumour progression.

Authors: C-J Chang; M-C Hung
Journal: Br J Cancer Date: 2011-12-20 Impact factor: 7.640

8 in total

6 in total

1. A Y2H-seq approach defines the human protein methyltransferase interactome.

Authors: Mareike Weimann; Arndt Grossmann; Jonathan Woodsmith; Ziya Özkan; Petra Birth; David Meierhofer; Nouhad Benlasfer; Taras Valovka; Bernd Timmermann; Erich E Wanker; Sascha Sauer; Ulrich Stelzl
Journal: Nat Methods Date: 2013-03-03 Impact factor: 28.547

Titivated for destruction: the methyl degron.

1. PRC2 directly methylates GATA4 and represses its transcriptional activity.

2. Naming a targeting signal.

3. Methylation, a new epigenetic mark for protein stability.

4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

Review 5. Readers of histone modifications.

6. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

Review 7. Diversity of degradation signals in the ubiquitin-proteasome system.

Review 8. The role of EZH2 in tumour progression.

1. A Y2H-seq approach defines the human protein methyltransferase interactome.

2. Ezh2 promotes TRβ lysine methylation-mediated degradation in hepatocellular carcinoma.

3. The ribosome: A hot spot for the identification of new types of protein methyltransferases.

4. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.

5. SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1.

6. Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4^DCAF5 ubiquitin ligase.