BACKGROUND: Convergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala-PFC functional connectivity abnormalities in treatment-naive subjects with MDD. METHODS: Resting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala-PFC functional connectivity was compared between the MDD and HC groups. RESULTS: Decreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p < 0.05, corrected). CONCLUSIONS: The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.
BACKGROUND: Convergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala-PFC functional connectivity abnormalities in treatment-naive subjects with MDD. METHODS: Resting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala-PFC functional connectivity was compared between the MDD and HC groups. RESULTS: Decreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p < 0.05, corrected). CONCLUSIONS: The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.
Authors: Moriah E Thomason; Hilary A Marusak; Maria A Tocco; Angela M Vila; Olivia McGarragle; David R Rosenberg Journal: Soc Cogn Affect Neurosci Date: 2015-04-02 Impact factor: 3.436
Authors: Mary L Phillips; Henry W Chase; Yvette I Sheline; Amit Etkin; Jorge R C Almeida; Thilo Deckersbach; Madhukar H Trivedi Journal: Am J Psychiatry Date: 2015-02-01 Impact factor: 18.112
Authors: Nobuko Kemmotsu; N Erkut Kucukboyaci; Christopher E Cheng; Holly M Girard; Evelyn S Tecoma; Vicente J Iragui; Carrie R McDonald Journal: Epilepsy Behav Date: 2013-10-28 Impact factor: 2.937
Authors: Tiffany C Ho; Colm G Connolly; Eva Henje Blom; Kaja Z LeWinn; Irina A Strigo; Martin P Paulus; Guido Frank; Jeffrey E Max; Jing Wu; Melanie Chan; Susan F Tapert; Alan N Simmons; Tony T Yang Journal: Biol Psychiatry Date: 2014-09-16 Impact factor: 13.382