Yue Li1, Liang Guo. 1. Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Abstract
PURPOSE: Wave intensity (WI) is a set of new hemodynamic indexes (W1 , W2 , and NA) based on the calculation of (dp/dt) × (dv/dt) on any artery. We assessed the value of carotid WI analysis for differentiating nonobstructive hypertrophic cardiomyopathy (NOHCM) from left ventricular hypertrophy secondary to hypertension (LVHSH). METHODS: Nineteen NOHCM, 34 LVHSH, and 37 normal controls (NC) underwent conventional echocardiographic examination and carotid WI analysis performed with an Aloka α10 sonographic system (Alok, Tokyo, Japan) with real-time wave intensity calculation software. RESULTS: W1 was higher in NOHCM (11,830 ± 7,850 mmHg·m·s(-3) ) and in LVHSH (13,670 ± 13,490 mmHg·m·s(-3) ) than in NC (7,010 ± 3,620 mmHg·m·s(-3) ). W2 was lower in NOHCM (850 ± 870 mmHg·m·s(-3) ) than in LVHSH (2,310 ± 1,390 mmHg·m·s(-3) , p < 0.01) and in NC (1,650 ± 960 mmHg·m·s(-3) , p < 0.01). Using W2 ≤ 1,100 mmHg·m·s(-3) as a threshold for differentiating NOHCM from LVHSH yielded an 84.2% sensitivity and 82.4% specificity. NA was higher in LVHSH (57.55 ± 57.82 mmHg·m·s(-2) ) than in NOHCM (34.24 ± 13.03 mmHg·m·s(-2) , p < 0.05) and in NC (31.67 ± 23.05 mmHg·m·s(-2) , p < 0.05). Using NA ≤40 mmHg·m·s(-2) as a threshold for differentiating NOHCM from LVHSH yielded a 63.2% sensitivity and 70.6% specificity. CONCLUSIONS: W2 and NA indexes derived from carotid WI analysis may be helpful for differentiating NOHCM from LVHSH.
PURPOSE: Wave intensity (WI) is a set of new hemodynamic indexes (W1 , W2 , and NA) based on the calculation of (dp/dt) × (dv/dt) on any artery. We assessed the value of carotid WI analysis for differentiating nonobstructive hypertrophic cardiomyopathy (NOHCM) from left ventricular hypertrophy secondary to hypertension (LVHSH). METHODS: Nineteen NOHCM, 34 LVHSH, and 37 normal controls (NC) underwent conventional echocardiographic examination and carotid WI analysis performed with an Aloka α10 sonographic system (Alok, Tokyo, Japan) with real-time wave intensity calculation software. RESULTS: W1 was higher in NOHCM (11,830 ± 7,850 mmHg·m·s(-3) ) and in LVHSH (13,670 ± 13,490 mmHg·m·s(-3) ) than in NC (7,010 ± 3,620 mmHg·m·s(-3) ). W2 was lower in NOHCM (850 ± 870 mmHg·m·s(-3) ) than in LVHSH (2,310 ± 1,390 mmHg·m·s(-3) , p < 0.01) and in NC (1,650 ± 960 mmHg·m·s(-3) , p < 0.01). Using W2 ≤ 1,100 mmHg·m·s(-3) as a threshold for differentiating NOHCM from LVHSH yielded an 84.2% sensitivity and 82.4% specificity. NA was higher in LVHSH (57.55 ± 57.82 mmHg·m·s(-2) ) than in NOHCM (34.24 ± 13.03 mmHg·m·s(-2) , p < 0.05) and in NC (31.67 ± 23.05 mmHg·m·s(-2) , p < 0.05). Using NA ≤40 mmHg·m·s(-2) as a threshold for differentiating NOHCM from LVHSH yielded a 63.2% sensitivity and 70.6% specificity. CONCLUSIONS: W2 and NA indexes derived from carotid WI analysis may be helpful for differentiating NOHCM from LVHSH.
Authors: Denise L Smith; Jacob P DeBlois; Margaret Wharton; Patricia C Fehling; Sushant M Ranadive Journal: Eur J Appl Physiol Date: 2015-06-26 Impact factor: 3.078