Literature DB >> 23190340

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response.

Francisco J Quintana1.   

Abstract

Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can influence the immune response and the development of autoimmune diseases. AHR also provides a target for therapeutic intervention in immune-mediated disorders. In this review, we discuss the role of AHR in the regulation of T-cell differentiation and autoimmunity.
© 2012 Blackwell Publishing Ltd.

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Year:  2013        PMID： 23190340      PMCID： PMC3573271          DOI： 10.1111/imm.12046

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  110 in total

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4.  Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.

Authors:  Y D Wei; H Helleberg; U Rannug; A Rannug
Journal:  Chem Biol Interact       Date:  1998-03-12       Impact factor: 5.192

5.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Authors:  S Sakaguchi; N Sakaguchi; M Asano; M Itoh; M Toda
Journal:  J Immunol       Date:  1995-08-01       Impact factor: 5.422

Review 6.  Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor.

Authors:  Oliver Hankinson
Journal:  Arch Biochem Biophys       Date:  2005-01-15       Impact factor: 4.013

7.  Activation of the Ah receptor by tryptophan and tryptophan metabolites.

Authors:  S Heath-Pagliuso; W J Rogers; K Tullis; S D Seidel; P H Cenijn; A Brouwer; M S Denison
Journal:  Biochemistry       Date:  1998-08-18       Impact factor: 3.162

8.  Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.

Authors:  P Fernandez-Salguero; T Pineau; D M Hilbert; T McPhail; S S Lee; S Kimura; D W Nebert; S Rudikoff; J M Ward; F J Gonzalez
Journal:  Science       Date:  1995-05-05       Impact factor: 47.728

9.  A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

Authors:  H Groux; A O'Garra; M Bigler; M Rouleau; S Antonenko; J E de Vries; M G Roncarolo
Journal:  Nature       Date:  1997-10-16       Impact factor: 49.962

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Authors:  S Sakaguchi; T Takahashi; Y Nishizuka
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307
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  46 in total

Review 1.  Control of immune-mediated pathology via the aryl hydrocarbon receptor.

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4.  The Aryl Hydrocarbon Receptor Modulates Production of Cytokines and Reactive Oxygen Species and Development of Myocarditis during Trypanosoma cruzi Infection.

Authors:  Andréia Barroso; Melisa Gualdrón-López; Lísia Esper; Fátima Brant; Ronan R S Araújo; Matheus B H Carneiro; Thiago V Ávila; Danielle G Souza; Leda Q Vieira; Milene A Rachid; Herbert B Tanowitz; Mauro M Teixeira; Fabiana S Machado
Journal:  Infect Immun       Date:  2016-09-19       Impact factor: 3.441

5.  Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase.

Authors:  Hsueh-Chun Wang; Tzu-Hsuan Wong; Li-Ting Wang; Hsiang-Han Su; Hsiu-Yueh Yu; Ai-Hsuan Wu; Yu-Chun Lin; Hua-Ling Chen; Jau-Ling Suen; Shih-Hsien Hsu; Li-Chen Chen; Yufeng Zhou; Shau-Ku Huang
Journal:  Cell Mol Immunol       Date:  2018-03-23       Impact factor: 11.530

6.  Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.

Authors:  Hsueh-Chun Wang; Kwei-Yan Liu; Li-Ting Wang; Shih-Hsien Hsu; Shao-Chun Wang; Shau-Ku Huang
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Review 7.  Emerging roles of xenobiotic detoxification enzymes in metabolic diseases.

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8.  Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

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Journal:  Nature       Date:  2014-07-10       Impact factor: 49.962

Review 9.  Role and therapeutic value of dendritic cells in central nervous system autoimmunity.

Authors:  F J Quintana; A Yeste; I D Mascanfroni
Journal:  Cell Death Differ       Date:  2014-08-29       Impact factor: 15.828

10.  Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells.

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Journal:  J Immunol       Date:  2015-11-11       Impact factor: 5.422
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