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Literature DB >> 23184773

Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

Jaehoon Chung¹, Huilin Shao, Thomas Reiner, David Issadore, Ralph Weissleder, Hakho Lee.

Abstract

A low-cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor-bearing mice.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 23184773 PMCID： PMC3508764 DOI： 10.1002/adhm.201200046

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

26 in total

1. Portable filter-based microdevice for detection and characterization of circulating tumor cells.

Authors: Henry K Lin; Siyang Zheng; Anthony J Williams; Marija Balic; Susan Groshen; Howard I Scher; Martin Fleisher; Walter Stadler; Ram H Datar; Yu-Chong Tai; Richard J Cote
Journal: Clin Cancer Res Date: 2010-09-28 Impact factor: 12.531

2. Highly-efficient single-cell capture in microfluidic array chips using differential hydrodynamic guiding structures.

Authors: Jaehoon Chung; Young-Ji Kim; Euisik Yoon
Journal: Appl Phys Lett Date: 2011-03-21 Impact factor: 3.791

Review 3. A perspective on cancer cell metastasis.

Authors: Christine L Chaffer; Robert A Weinberg
Journal: Science Date: 2011-03-25 Impact factor: 47.728

4. Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody.

Authors: Jason P Gleghorn; Erica D Pratt; Denise Denning; He Liu; Neil H Bander; Scott T Tagawa; David M Nanus; Paraskevi A Giannakakou; Brian J Kirby
Journal: Lab Chip Date: 2009-11-16 Impact factor: 6.799

5. Size-selective microcavity array for rapid and efficient detection of circulating tumor cells.

Authors: Masahito Hosokawa; Taishi Hayata; Yorikane Fukuda; Atsushi Arakaki; Tomoko Yoshino; Tsuyoshi Tanaka; Tadashi Matsunaga
Journal: Anal Chem Date: 2010-08-01 Impact factor: 6.986

6. The evolving war on cancer.

Authors: Daniel A Haber; Nathanael S Gray; Jose Baselga
Journal: Cell Date: 2011-04-01 Impact factor: 41.582

7. Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation.

Authors: Ali Asgar S Bhagat; Han Wei Hou; Leon D Li; Chwee Teck Lim; Jongyoon Han
Journal: Lab Chip Date: 2011-04-19 Impact factor: 6.799

8. Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice.

Authors: N Hanna; I J Fidler
Journal: Cancer Res Date: 1981-02 Impact factor: 12.701

9. Tumor self-seeding by circulating cancer cells.

Authors: Mi-Young Kim; Thordur Oskarsson; Swarnali Acharyya; Don X Nguyen; Xiang H-F Zhang; Larry Norton; Joan Massagué
Journal: Cell Date: 2009-12-24 Impact factor: 41.582

10. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.

Authors: S Koop; I C MacDonald; K Luzzi; E E Schmidt; V L Morris; M Grattan; R Khokha; A F Chambers; A C Groom
Journal: Cancer Res Date: 1995-06-15 Impact factor: 12.701

12 in total

1. Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip.

Authors: Jaehoon Chung; David Issadore; Adeeti Ullal; Kyungheon Lee; Ralph Weissleder; Hakho Lee
Journal: Biomicrofluidics Date: 2013-09-17 Impact factor: 2.800

2. Traceable clonal culture and chemodrug assay of heterogeneous prostate carcinoma PC3 cells in microfluidic single cell array chips.

Authors: Jaehoon Chung; Patrick N Ingram; Tom Bersano-Begey; Euisik Yoon
Journal: Biomicrofluidics Date: 2014-11-14 Impact factor: 2.800

Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

1. Portable filter-based microdevice for detection and characterization of circulating tumor cells.

2. Highly-efficient single-cell capture in microfluidic array chips using differential hydrodynamic guiding structures.

Review 3. A perspective on cancer cell metastasis.

4. Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody.

5. Size-selective microcavity array for rapid and efficient detection of circulating tumor cells.

6. The evolving war on cancer.

7. Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation.

8. Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice.

9. Tumor self-seeding by circulating cancer cells.

10. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.

1. Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip.

2. Traceable clonal culture and chemodrug assay of heterogeneous prostate carcinoma PC3 cells in microfluidic single cell array chips.

Review 3. Recent advances in microfluidic methods in cancer liquid biopsy.

Review 4. The Tumor Microenvironment: An Introduction to the Development of Microfluidic Devices.

5. Ascites analysis by a microfluidic chip allows tumor-cell profiling.

Review 6. Benchtop technologies for circulating tumor cells separation based on biophysical properties.

Review 7. Microfluidic chip-based technologies: emerging platforms for cancer diagnosis.

8. Fluorimetric Mercury Test Strips with Suppressed "Coffee Stains" by a Bio-inspired Fabrication Strategy.

9. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Review 10. Diagnostic technologies for circulating tumour cells and exosomes.