BACKGROUND: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. METHODS: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥105 mmHg and HbA1c≥7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD. RESULTS: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR=0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. CONCLUSIONS: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.
BACKGROUND: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. METHODS: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥105 mmHg and HbA1c≥7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD. RESULTS: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabeticmen, OR=0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. CONCLUSIONS: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.
Authors: Auke H Brantsma; Stephan J L Bakker; Hans L Hillege; Dick de Zeeuw; Paul E de Jong; Ronald T Gansevoort Journal: Nephrol Dial Transplant Date: 2008-07-18 Impact factor: 5.992
Authors: Angela D Liese; Ralph B D'Agostino; Richard F Hamman; Patrick D Kilgo; Jean M Lawrence; Lenna L Liu; Beth Loots; Barbara Linder; Santica Marcovina; Beatriz Rodriguez; Debra Standiford; Desmond E Williams Journal: Pediatrics Date: 2006-10 Impact factor: 7.124
Authors: P Fioretto; M Mauer; E Brocco; M Velussi; F Frigato; B Muollo; M Sambataro; C Abaterusso; B Baggio; G Crepaldi; R Nosadini Journal: Diabetologia Date: 1996-12 Impact factor: 10.122
Authors: George L Bakris; Matthew R Weir; Shahnaz Shanifar; Zhongxin Zhang; Janice Douglas; David J van Dijk; Barry M Brenner Journal: Arch Intern Med Date: 2003-07-14
Authors: Vincent Rigalleau; Catherine Lasseur; Christelle Raffaitin; Marie-Christine Beauvieux; Nicole Barthe; Philippe Chauveau; Christian Combe; Henri Gin Journal: Diabetes Care Date: 2007-05-07 Impact factor: 19.112
Authors: Lesley A Stevens; Jane Manzi; Andrew S Levey; Jing Chen; Amy E Deysher; Tom Greene; Emilio D Poggio; Christopher H Schmid; Michael W Steffes; Yaping Lucy Zhang; Frederick Van Lente; Josef Coresh Journal: Am J Kidney Dis Date: 2007-07 Impact factor: 8.860
Authors: Anna R Kahkoska; Scott Isom; Jasmin Divers; Elizabeth J Mayer-Davis; Lawrence Dolan; Amy S Shah; Maryam Afkarian; David J Pettitt; Jean M Lawrence; Santica Marcovina; Sharon H Saydah; Dana Dabelea; David M Maahs; Amy K Mottl Journal: J Diabetes Complications Date: 2018-10-04 Impact factor: 3.219
Authors: Katherine D Westreich; Scott Isom; Jasmin Divers; Ralph D'Agostino; Jean M Lawrence; Roopa Kanakatti Shankar; Lawrence M Dolan; Giuseppina Imperatore; Dana Dabelea; Elizabeth J Mayer-Davis; Amy K Mottl Journal: J Diabetes Complications Date: 2020-10-23 Impact factor: 3.219