David H Abramson1, Jasmine H Francis2, Ira J Dunkel3, Brian P Marr2, Scott E Brodie4, Y Pierre Gobin5. 1. Department of Ophthalmology at Weill-Cornell Medical School, New York, New York; Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center, New York, New York. Electronic address: abramsod@mskcc.org. 2. Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center, New York, New York. 3. Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Pediatrics, Weill-Cornell Medical Center, New York, New York. 4. Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York. 5. Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Neurosurgery, Neurology, and Radiology at Weill-Cornell Medical, New York, New York.
Abstract
OBJECTIVE: To determine the incidence and timing of new intraocular tumor foci in genetic retinoblastoma cases after treatment with ophthalmic artery chemosurgery (OAC). DESIGN: Single-center retrospective review of all genetic retinoblastoma cases managed at Memorial Sloan-Kettering Cancer Center/Weil-Cornell Medical School since May 2006. PARTICIPANTS: Eighty-one patients (80 with bilateral disease and 1 with unilateral disease with a family history) with genetic retinoblastoma, with a total of 116 eyes treated with OAC since May 2006. METHODS: Retrospective, single-institution review of patients with bilateral retinoblastoma and unilateral retinoblastoma with a positive family history. New tumors were assessed by clinical notes, retinal drawings, and RetCam digital imaging (Clarity Medical Systems, Pleasanton, CA). MAIN OUTCOME MEASURES: New intraocular retinoblastoma tumors after treatment with OAC. RESULTS: Forty-one eyes were treated primarily with OAC (treatment-naïve group) and 75 eyes were treated with OAC after prior treatment with systemic chemotherapy, external beam radiation, or both and focal techniques. Of the 41 treatment-naïve eyes, a new intraocular tumor (one focus) subsequently developed in 1 eye. Of the 75 previously treated eyes, new tumors (single focus in each eye) subsequently developed in 6 eyes. CONCLUSIONS: Eyes receiving OAC demonstrate fewer new intraocular retinoblastomas after radiation or systemic chemotherapy than has been reported in the literature. This suggests that ophthalmoscopically undetectable tumors are present at the initial diagnosis and effectively are eliminated as a result of OAC.
OBJECTIVE: To determine the incidence and timing of new intraocular tumor foci in genetic retinoblastoma cases after treatment with ophthalmic artery chemosurgery (OAC). DESIGN: Single-center retrospective review of all genetic retinoblastoma cases managed at Memorial Sloan-Kettering Cancer Center/Weil-Cornell Medical School since May 2006. PARTICIPANTS: Eighty-one patients (80 with bilateral disease and 1 with unilateral disease with a family history) with genetic retinoblastoma, with a total of 116 eyes treated with OAC since May 2006. METHODS: Retrospective, single-institution review of patients with bilateral retinoblastoma and unilateral retinoblastoma with a positive family history. New tumors were assessed by clinical notes, retinal drawings, and RetCam digital imaging (Clarity Medical Systems, Pleasanton, CA). MAIN OUTCOME MEASURES: New intraocular retinoblastoma tumors after treatment with OAC. RESULTS: Forty-one eyes were treated primarily with OAC (treatment-naïve group) and 75 eyes were treated with OAC after prior treatment with systemic chemotherapy, external beam radiation, or both and focal techniques. Of the 41 treatment-naïve eyes, a new intraocular tumor (one focus) subsequently developed in 1 eye. Of the 75 previously treated eyes, new tumors (single focus in each eye) subsequently developed in 6 eyes. CONCLUSIONS: Eyes receiving OAC demonstrate fewer new intraocular retinoblastomas after radiation or systemic chemotherapy than has been reported in the literature. This suggests that ophthalmoscopically undetectable tumors are present at the initial diagnosis and effectively are eliminated as a result of OAC.
Authors: Christina Scelfo; Jasmine H Francis; Vikas Khetan; Thomas Jenkins; Brian Marr; David H Abramson; Carol L Shields; Jacob Pe'er; Francis Munier; Jesse Berry; J William Harbour; Andrey Yarovoy; Evandro Lucena; Timothy G Murray; Pooja Bhagia; Evelyn Paysse; Samuray Tuncer; Guillermo L Chantada; Annette C Moll; Tatiana Ushakova; David A Plager; Islamov Ziyovuddin; Carlos A Leal; Miguel A Materin; Xun-Da Ji; Jose W Cursino; Rodrigo Polania; Hayyam Kiratli; Charlotta All-Ericsson; Rejin Kebudi; Santosh G Honavar; Vicktoria Vishnevskia-Dai; Sidnel Epelman; Anthony B Daniels; Jeanie D Ling; Fousseyni Traore; Marco A Ramirez-Ortiz Journal: Int J Ophthalmol Date: 2017-06-18 Impact factor: 1.779
Authors: Nicolas Alessandro Yannuzzi; Jasmine H Francis; Brian P Marr; Irina Belinsky; Ira J Dunkel; Yves Pierre Gobin; David Harold Abramson Journal: JAMA Ophthalmol Date: 2015-09 Impact factor: 7.389
Authors: Shailendra Joshi; Rajinder P Singh-Moon; Jason A Ellis; Durba B Chaudhuri; Mei Wang; Roberto Reif; Jeffrey N Bruce; Irving J Bigio; Robert M Straubinger Journal: Neurosurgery Date: 2015-01 Impact factor: 4.654
Authors: Catherine Y Liu; Gowtham Jonna; Jasmine H Francis; Brian P Marr; David H Abramson; Scott E Brodie Journal: Doc Ophthalmol Date: 2013-11-09 Impact factor: 2.379
Authors: Jason A Ellis; Matei Banu; Shaolie S Hossain; Rajinder Singh-Moon; Sean D Lavine; Jeffrey N Bruce; Shailendra Joshi Journal: J Drug Deliv Date: 2015-12-30