Literature DB >> 23175370

Aerosol transmission of chronic wasting disease in white-tailed deer.

Nathaniel D Denkers1, Jeanette Hayes-Klug, Kelly R Anderson, Davis M Seelig, Nicholas J Haley, Sallie J Dahmes, David A Osborn, Karl V Miller, Robert J Warren, Candace K Mathiason, Edward A Hoover.   

Abstract

While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose >20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.

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Year:  2012        PMID： 23175370      PMCID： PMC3554158          DOI： 10.1128/JVI.02852-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

Review 1.  Sensory coding of pheromone signals in mammals.

Authors:  C Dulac
Journal:  Curr Opin Neurobiol       Date:  2000-08       Impact factor: 6.627

Review 2.  The pathogenesis and diagnosis of foot-and-mouth disease.

Authors:  S Alexandersen; Z Zhang; A I Donaldson; A J M Garland
Journal:  J Comp Pathol       Date:  2003-07       Impact factor: 1.311

3.  Vomeronasal organ: pheromone recognition with a twist.

Authors:  Natasha Thorne; Hubert Amrein
Journal:  Curr Biol       Date:  2003-03-18       Impact factor: 10.834

4.  A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.

Authors:  L Buck; R Axel
Journal:  Cell       Date:  1991-04-05       Impact factor: 41.582

5.  Efferent control of stimulus access to the hamster vomeronasal organ.

Authors:  M Meredith; R J O'Connell
Journal:  J Physiol       Date:  1979-01       Impact factor: 5.182

6.  Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus).

Authors:  Christina J Sigurdson; Elizabeth S Williams; Michael W Miller; Terry R Spraker; Katherine I O'Rourke; Edward A Hoover
Journal:  J Gen Virol       Date:  1999-10       Impact factor: 3.891

7.  The most infectious prion protein particles.

Authors:  Jay R Silveira; Gregory J Raymond; Andrew G Hughson; Richard E Race; Valerie L Sim; Stanley F Hayes; Byron Caughey
Journal:  Nature       Date:  2005-09-08       Impact factor: 49.962

8.  The ferret's vomeronasal organ and accessory olfactory bulb: effect of hormone manipulation in adult males and females.

Authors:  K R Kelliher; M J Baum; M Meredith
Journal:  Anat Rec       Date:  2001-07-01

9.  Aerosol exposure of white-tailed deer (Odocoileus virginianus) to Mycobacterium bovis.

Authors:  Mitchell V Palmer; W Ray Waters; Diana L Whipple
Journal:  J Wildl Dis       Date:  2003-10       Impact factor: 1.535

10.  Environmental sources of prion transmission in mule deer.

Authors:  Michael W Miller; Elizabeth S Williams; N Thomas Hobbs; Lisa L Wolfe
Journal:  Emerg Infect Dis       Date:  2004-06       Impact factor: 6.883
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  45 in total

Review 1.  Prions and the potential transmissibility of protein misfolding diseases.

Authors:  Allison Kraus; Bradley R Groveman; Byron Caughey
Journal:  Annu Rev Microbiol       Date:  2013-06-28       Impact factor: 15.500

2.  Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions.

Authors:  Kristen A Davenport; Clare E Hoover; Nathaniel D Denkers; Candace K Mathiason; Edward A Hoover
Journal:  J Clin Microbiol       Date:  2018-08-27       Impact factor: 5.948

3.  Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion.

Authors:  Davin M Henderson; Joanne M Tennant; Nicholas J Haley; Nathaniel D Denkers; Candace K Mathiason; Edward A Hoover
Journal:  J Gen Virol       Date:  2017-07-13       Impact factor: 3.891

4.  Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations.

Authors:  Alan M Elder; Davin M Henderson; Amy V Nalls; Edward A Hoover; Anthony E Kincaid; Jason C Bartz; Candace K Mathiason
Journal:  J Virol       Date:  2015-07       Impact factor: 5.103

5.  Potential role of soil properties in the spread of CWD in western Canada.

Authors:  Alsu Kuznetsova; Debbie McKenzie; Pamela Banser; Tariq Siddique; Judd M Aiken
Journal:  Prion       Date:  2014 Jan-Feb       Impact factor: 3.931

6.  Protocol for aerosol-free recombinant production and NMR analysis of prion proteins.

Authors:  Peter Rehbein; Krishna Saxena; Kai Schlepckow; Harald Schwalbe
Journal:  J Biomol NMR       Date:  2014-04-26       Impact factor: 2.835

7.  Enhanced prion detection in biological samples by magnetic particle extraction and real-time quaking-induced conversion.

Authors:  Nathaniel D Denkers; Davin M Henderson; Candace K Mathiason; Edward A Hoover
Journal:  J Gen Virol       Date:  2016-05-27       Impact factor: 3.891

8.  Using White-tailed Deer (Odocoileus virginianus) in Infectious Disease Research.

Authors:  Mitchell V Palmer; Rebecca J Cox; W Ray Waters; Tyler C Thacker; Diana L Whipple
Journal:  J Am Assoc Lab Anim Sci       Date:  2017-07-01       Impact factor: 1.232

9.  A test for Creutzfeldt-Jakob disease using nasal brushings.

Authors:  Christina D Orrú; Matilde Bongianni; Giovanni Tonoli; Sergio Ferrari; Andrew G Hughson; Bradley R Groveman; Michele Fiorini; Maurizio Pocchiari; Salvatore Monaco; Byron Caughey; Gianluigi Zanusso
Journal:  N Engl J Med       Date:  2014-08-07       Impact factor: 91.245

10.  Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling.

Authors:  Kristen A Davenport; Brittany A Mosher; Brian M Brost; Davin M Henderson; Nathaniel D Denkers; Amy V Nalls; Erin McNulty; Candace K Mathiason; Edward A Hoover
Journal:  J Clin Microbiol       Date:  2017-12-26       Impact factor: 5.948
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