Literature DB >> 2317317

5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.

K P Lesch1, J Disselkamp-Tietze, A Schmidtke.   

Abstract

Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulated during AMI treatment.

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Year:  1990        PMID： 2317317     DOI： 10.1007/bf01257081

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  10 in total

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Authors:  P H Hutson; T P Donohoe; G Curzon
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Review 3.  Use of serotonergic agents in the clinical assessment of central serotonin function.

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5.  Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans.

Authors:  K P Lesch; B Poten; K Söhnle; H M Schulte
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

6.  Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat.

Authors:  G M Goodwin; R J De Souza; A R Green
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

7.  Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors.

Authors:  G A Gudelsky; J I Koenig; H Y Meltzer
Journal:  Neuropharmacology       Date:  1986-12       Impact factor: 5.250

8.  The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).

Authors:  G M Goodwin; R J De Souza; A R Green; D J Heal
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

9.  Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression.

Authors:  K P Lesch; S Mayer; J Disselkamp-Tietze; A Hoh; G Schoellnhammer; H M Schulte
Journal:  Life Sci       Date:  1990       Impact factor: 5.037

10.  The effect of 8-OH-DPAT on temperature in the rat and its modification by chronic antidepressant treatments.

Authors:  K M Wozniak; C S Aulakh; J L Hill; D L Murphy
Journal:  Pharmacol Biochem Behav       Date:  1988-06       Impact factor: 3.533
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Authors:  J Hennig; C Opper; S Huwe; P Netter
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients.

Authors:  Richard J Porter; Peter Gallagher; Stuart Watson; Margaret S Smith; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2003-05-01       Impact factor: 4.530

Review 5.  Corticosteroid-serotonin interactions in depression: a review of the human evidence.

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Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

Review 6.  Serotonin-1A receptor imaging in recurrent depression: replication and literature review.

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7.  Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects.

Authors:  Y Gelfin; B Lerer; K P Lesch; M Gorfine; B Allolio
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

Review 8.  Gene-environment interaction and the genetics of depression.

Authors:  Klaus Peter Lesch
Journal:  J Psychiatry Neurosci       Date:  2004-05       Impact factor: 6.186

9.  5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression.

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10.  Mechanisms of Psychiatric Comorbidities in Epilepsy.

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