Literature DB >> 1980461

Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans.

K P Lesch1, B Poten, K Söhnle, H M Schulte.   

Abstract

The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. The response was attenuated by the nonselective 5-HT1/2 receptor antagonist metergoline and was completely antagonized by the nonselective beta-adrenoceptor antagonist pindolol, which interacts stereoselectively with the 5-HT1A receptor. The selective beta 1-adrenergic antagonist betaxolol had no effect. The findings indicate that IPS-induced hypothermia specifically involves activation of (presynaptic) 5-HT1A receptors. Therefore, the hypothermic response to IPS may provide a convenient in vivo paradigma to assess the function of the presynaptic 5-HT receptor in affective disorders and its involvement in the effects of psychotropic drugs.

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Year:  1990        PMID： 1980461     DOI： 10.1007/bf02657050

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

Review 1.  5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization.

Authors:  S J Peroutka
Journal:  Trends Neurosci       Date:  1988-11       Impact factor: 13.837

Review 2.  Use of serotonergic agents in the clinical assessment of central serotonin function.

Authors:  D L Murphy; E A Mueller; N A Garrick; C S Aulakh
Journal:  J Clin Psychiatry       Date:  1986-04       Impact factor: 4.384

3.  Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites.

Authors:  T Glaser; J Traber
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-05       Impact factor: 3.000

4.  Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.

Authors:  J Traber; M A Davies; W U Dompert; T Glaser; T Schuurman; P R Seidel
Journal:  Brain Res Bull       Date:  1984-06       Impact factor: 4.077

5.  Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.

Authors:  G Engel; M Göthert; D Hoyer; E Schlicker; K Hillenbrand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-01       Impact factor: 3.000

6.  Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors.

Authors:  G A Gudelsky; J I Koenig; H Y Meltzer
Journal:  Neuropharmacology       Date:  1986-12       Impact factor: 5.250

7.  The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra.

Authors:  P Schoeffter; C Waeber; J M Palacios; D Hoyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

8.  The effect of 8-OH-DPAT on temperature in the rat and its modification by chronic antidepressant treatments.

Authors:  K M Wozniak; C S Aulakh; J L Hill; D L Murphy
Journal:  Pharmacol Biochem Behav       Date:  1988-06       Impact factor: 3.533
  8 in total
  18 in total

1.  Effects of sustained (+/-)pindolol administration on serotonin neurotransmission in rats.

Authors:  N Haddjeri; P Blier
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

2.  An increased hypothermic response to buspirone in patients with major depression.

Authors:  Ricard Navinés; Esther Gómez-Gil; Rocío Martín-Santos; María J Martínez de Osaba; Maria Luisa Imaz; Cristóbal Gastó
Journal:  Psychopharmacology (Berl)       Date:  2006-08-29       Impact factor: 4.530

Review 3.  The 5-HT receptor--G-protein--effector system complex in depression. I. Effect of glucocorticoids.

Authors:  K P Lesch; B Lerer
Journal:  J Neural Transm Gen Sect       Date:  1991

4.  Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers.

Authors:  I M Anderson; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

5.  5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.

Authors:  K P Lesch; J Disselkamp-Tietze; A Schmidtke
Journal:  J Neural Transm Gen Sect       Date:  1990

6.  Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder.

Authors:  K P Lesch; A Hoh; H M Schulte; M Osterheider; T Müller
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram.

Authors:  L Arborelius; G G Nomikos; P Grillner; P Hertel; B B Höök; U Hacksell; T H Svensson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

8.  Evidence for postsynaptic mediation of the hypothermic effect of 5-HT1A receptor activation.

Authors:  M T O'Connell; G S Sarna; G Curzon
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

9.  Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects.

Authors:  Y Gelfin; B Lerer; K P Lesch; M Gorfine; B Allolio
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

10.  Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation.

Authors:  Lotta Arborelius; Brian W Hawks; Michael J Owens; Paul M Plotsky; Charles B Nemeroff
Journal:  Psychopharmacology (Berl)       Date:  2004-06-02       Impact factor: 4.530
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