Literature DB >> 23172610

Exploring an orbitrap analyzer for the characterization of intact antibodies by native mass spectrometry.

Sara Rosati1, Rebecca J Rose, Natalie J Thompson, Esther van Duijn, Eugen Damoc, Eduard Denisov, Alexander Makarov, Albert J R Heck.   

Abstract

Antibody profiling: native mass spectrometry analysis of intact antibodies can be achieved with improved speed, sensitivity, and mass resolution by using a modified orbitrap instrument. Complex mixtures of monoclonal antibodies can be resolved and their glycan "fingerprints" can be profiled. Noncovalent interactions are maintained, thus allowing antibody-antigen binding to be measured.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23172610     DOI： 10.1002/anie.201206745

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  37 in total

1.  Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry.

Authors:  Natalie J Thompson; Linda J A Hendriks; John de Kruif; Mark Throsby; Albert J R Heck
Journal:  MAbs       Date:  2014 Jan-Feb       Impact factor: 5.857

Review 2.  The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes.

Authors:  Elisabetta Boeri Erba; Carlo Petosa
Journal:  Protein Sci       Date:  2015-03-31       Impact factor: 6.725

3.  Boundaries of mass resolution in native mass spectrometry.

Authors:  Philip Lössl; Joost Snijder; Albert J R Heck
Journal:  J Am Soc Mass Spectrom       Date:  2014-04-04       Impact factor: 3.109

4.  Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry.

Authors:  Sara Rosati; Yang Yang; Arjan Barendregt; Albert J R Heck
Journal:  Nat Protoc       Date:  2014-03-27       Impact factor: 13.491

5.  Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry.

Authors:  Jiang Zhang; Rachel R Ogorzalek Loo; Joseph A Loo
Journal:  J Am Soc Mass Spectrom       Date:  2017-07-28       Impact factor: 3.109

6.  Recent Developments in Gas-Phase Ion/Ion Reactions for Analytical Mass Spectrometry.

Authors:  David J Foreman; Scott A McLuckey
Journal:  Anal Chem       Date:  2019-11-26       Impact factor: 6.986

7.  Interpretation and deconvolution of nanodisc native mass spectra.

Authors:  Michael T Marty; Hao Zhang; Weidong Cui; Michael L Gross; Stephen G Sligar
Journal:  J Am Soc Mass Spectrom       Date:  2013-12-19       Impact factor: 3.109

8.  Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer.

Authors:  Luca Fornelli; Daniel Ayoub; Konstantin Aizikov; Xiaowen Liu; Eugen Damoc; Pavel A Pevzner; Alexander Makarov; Alain Beck; Yury O Tsybin
Journal:  J Proteomics       Date:  2017-02-27       Impact factor: 4.044

9.  Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

Authors:  Reginald McNulty; Ravi Kumar Lokareddy; Ankoor Roy; Yang Yang; Gabriel C Lander; Albert J R Heck; John E Johnson; Gino Cingolani
Journal:  J Mol Biol       Date:  2015-08-21       Impact factor: 5.469

10.  Native Proteomics in Discovery Mode Using Size-Exclusion Chromatography-Capillary Zone Electrophoresis-Tandem Mass Spectrometry.

Authors:  Xiaojing Shen; Qiang Kou; Ruiqiong Guo; Zhichang Yang; Daoyang Chen; Xiaowen Liu; Heedeok Hong; Liangliang Sun
Journal:  Anal Chem       Date:  2018-08-13       Impact factor: 6.986
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