Wei Xu1, Jian Shi, Xiang Li, Xin Zeng, Yong Lin. 1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Abstract
BACKGROUND: Endoscopic ultrasound (EUS) elastography is a novel method for visualization of tissue elasticity modulus during a conventional EUS examination. The reported yield of EUS elastography for the differentiation of benign and malignant pancreatic masses has shown variable results. The objective of this study was to assess the accuracy of EUS elastography by pooling data of available trials. METHODS: The Medline, PubMed, Embase, and Cochrane Central Trials databases were used to retrieve all the studies that assessed the diagnostic accuracy of EUS elastography for the differentiation of benign and malignant pancreatic masses. Pooling was carried out using a fixed-effect model when significant heterogeneity was not present; otherwise, the random-effect model was used. If there were less than four studies using the same diagnostic standard, forest plots were constructed without pooling. RESULTS: In six studies using the qualitative color pattern as the diagnostic standard, the sensitivity was 99% (95% confidence interval 98-100%) and the specificity was 74% (95% confidence interval 65-82%). The area under the curve under the summary receiver-operating characteristic was 0.9624. In three studies using the quantitative hue histogram value as the diagnostic standard, the sensitivity was 85-93% and the specificity was 64-76%. CONCLUSION: EUS elastography is a promising noninvasive technique for the differentiation of pancreatic masses with a high sensitivity, and may prove to be a valuable complementary method to EUS-FNA.
BACKGROUND: Endoscopic ultrasound (EUS) elastography is a novel method for visualization of tissue elasticity modulus during a conventional EUS examination. The reported yield of EUS elastography for the differentiation of benign and malignant pancreatic masses has shown variable results. The objective of this study was to assess the accuracy of EUS elastography by pooling data of available trials. METHODS: The Medline, PubMed, Embase, and Cochrane Central Trials databases were used to retrieve all the studies that assessed the diagnostic accuracy of EUS elastography for the differentiation of benign and malignant pancreatic masses. Pooling was carried out using a fixed-effect model when significant heterogeneity was not present; otherwise, the random-effect model was used. If there were less than four studies using the same diagnostic standard, forest plots were constructed without pooling. RESULTS: In six studies using the qualitative color pattern as the diagnostic standard, the sensitivity was 99% (95% confidence interval 98-100%) and the specificity was 74% (95% confidence interval 65-82%). The area under the curve under the summary receiver-operating characteristic was 0.9624. In three studies using the quantitative hue histogram value as the diagnostic standard, the sensitivity was 85-93% and the specificity was 64-76%. CONCLUSION: EUS elastography is a promising noninvasive technique for the differentiation of pancreatic masses with a high sensitivity, and may prove to be a valuable complementary method to EUS-FNA.
Authors: Kimberly A Kelly; Michael A Hollingsworth; Randall E Brand; Christina H Liu; Vikesh K Singh; Sudhir Srivastava; Ajay D Wasan; Dhiraj Yadav; Dana K Andersen Journal: Pancreas Date: 2015-11 Impact factor: 3.327
Authors: Paul D James; Zhao Wu Meng; Mei Zhang; Paul J Belletrutti; Rachid Mohamed; William Ghali; Derek J Roberts; Guillaume Martel; Steven J Heitman Journal: PLoS One Date: 2017-03-20 Impact factor: 3.240