Literature DB >> 23168825

Nonpharmacologic management of behavioral symptoms in dementia.

Laura N Gitlin1, Helen C Kales, Constantine G Lyketsos.   

Abstract

Behavioral symptoms such as repetitive speech, wandering, and sleep disturbances are a core clinical feature of Alzheimer disease and related dementias. If untreated, these behaviors can accelerate disease progression, worsen functional decline and quality of life, cause significant caregiver distress, and result in earlier nursing home placement. Systematic screening for behavioral symptoms in dementia is an important prevention strategy that facilitates early treatment of behavioral symptoms by identifying underlying causes and tailoring a treatment plan. First-line nonpharmacologic treatments are recommended because available pharmacologic treatments are only modestly effective, have notable risks, and do not effectively treat some of the behaviors that family members and caregivers find most distressing. Examples of nonpharmacologic treatments include provision of caregiver education and support, training in problem solving, and targeted therapy directed at the underlying causes for specific behaviors (eg, implementing nighttime routines to address sleep disturbances). Based on an actual case, we characterize common behavioral symptoms and describe a strategy for selecting evidence-based nonpharmacologic dementia treatments. Nonpharmacologic management of behavioral symptoms in dementia can significantly improve quality of life and patient-caregiver satisfaction.

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Year:  2012        PMID: 23168825      PMCID: PMC3711645          DOI: 10.1001/jama.2012.36918

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  71 in total

1.  Caregiver burden and neuropsychiatric symptoms in older adults with cognitive impairment: the Aging, Demographics, and Memory Study (ADAMS).

Authors:  Toru Okura; Kenneth M Langa
Journal:  Alzheimer Dis Assoc Disord       Date:  2011 Apr-Jun       Impact factor: 2.703

2.  Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: a randomized, controlled trial.

Authors:  Steven H Belle; Louis Burgio; Robert Burns; David Coon; Sara J Czaja; Dolores Gallagher-Thompson; Laura N Gitlin; Julie Klinger; Kathy Mann Koepke; Chin Chin Lee; Jennifer Martindale-Adams; Linda Nichols; Richard Schulz; Sidney Stahl; Alan Stevens; Laraine Winter; Song Zhang
Journal:  Ann Intern Med       Date:  2006-11-21       Impact factor: 25.391

3.  Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.

Authors:  Constantine G Lyketsos; Christopher C Colenda; Cornelia Beck; Karen Blank; Murali P Doraiswamy; Douglas A Kalunian; Kristine Yaffe
Journal:  Am J Geriatr Psychiatry       Date:  2006-07       Impact factor: 4.105

4.  Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.

Authors:  Lon S Schneider; Pierre N Tariot; Karen S Dagerman; Sonia M Davis; John K Hsiao; M Saleem Ismail; Barry D Lebowitz; Constantine G Lyketsos; J Michael Ryan; T Scott Stroup; David L Sultzer; Daniel Weintraub; Jeffrey A Lieberman
Journal:  N Engl J Med       Date:  2006-10-12       Impact factor: 91.245

5.  Enhancing quality of life of families who use adult day services: Short- and long-term effects of the adult day services plus program.

Authors:  Laura N Gitlin; Karen Reever; Marie P Dennis; Esther Mathieu; Walter W Hauck
Journal:  Gerontologist       Date:  2006-10

6.  Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease.

Authors:  Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäki; Janne Martikainen; Hannu Valtonen; Juhani Sivenius; Hilkka Soininen; Sirpa Hartikainen; Jaana Suhonen; Tuula Pirttilä
Journal:  Int J Geriatr Psychiatry       Date:  2010-10-29       Impact factor: 3.485

7.  Improving caregiver well-being delays nursing home placement of patients with Alzheimer disease.

Authors:  Mary S Mittelman; William E Haley; Olivio J Clay; David L Roth
Journal:  Neurology       Date:  2006-11-14       Impact factor: 9.910

8.  A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.

Authors:  Alistair Burns; Elaine Perry; Clive Holmes; Paul Francis; Julie Morris; Melanie-Jayne R Howes; Paul Chazot; George Lees; Clive Ballard
Journal:  Dement Geriatr Cogn Disord       Date:  2011-02-19       Impact factor: 2.959

9.  Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications.

Authors:  Helen C Kales; Marcia Valenstein; H Myra Kim; John F McCarthy; Dara Ganoczy; Francesca Cunningham; Frederic C Blow
Journal:  Am J Psychiatry       Date:  2007-10       Impact factor: 18.112

10.  Caring for patients with dementia: how good is the quality of care? Results from three health systems.

Authors:  Joshua Chodosh; Brian S Mittman; Karen I Connor; Stefanie D Vassar; Martin L Lee; Robert W DeMonte; Theodore G Ganiats; Lisa E Heikoff; Laurence Z Rubenstein; Richard D Della Penna; Barbara G Vickrey
Journal:  J Am Geriatr Soc       Date:  2007-08       Impact factor: 5.562

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  116 in total

1.  Antipsychotic Use in a Diverse Population With Dementia: A Retrospective Review of the National Alzheimer's Coordinating Center Database.

Authors:  Glen L Xiong; Teresa Filshtein; Laurel A Beckett; Ladson Hinton
Journal:  J Neuropsychiatry Clin Neurosci       Date:  2015       Impact factor: 2.198

Review 2.  Non-pharmacological Management of Behavioral Symptoms in Frontotemporal and Other Dementias.

Authors:  Cynthia Barton; Robin Ketelle; Jennifer Merrilees; Bruce Miller
Journal:  Curr Neurol Neurosci Rep       Date:  2016-02       Impact factor: 5.081

3.  Perceptions vs. evidence: therapeutic substitutes for antipsychotics in patients with dementia in long-term care.

Authors:  Brianne L Olivieri-Mui; John W Devlin; Aileen Ochoa; Danielle Schenck; Becky Briesacher
Journal:  Aging Ment Health       Date:  2017-01-12       Impact factor: 3.658

4.  Policy to Reduce Antipsychotic Use and Hospitalization of Nursing Home Residents With Dementia.

Authors:  Sijiu Wang; Helena Temkin-Greener; Yeates Conwell; Shubing Cai
Journal:  J Am Med Dir Assoc       Date:  2020-06-09       Impact factor: 4.669

5.  Clinicians' Perspectives on Barriers and Enablers of Optimal Prescribing in Patients with Dementia and Coexisting Conditions.

Authors:  Ariel R Green; Patricia Lee; Emily Reeve; Jennifer L Wolff; Chi Chiung Grace Chen; Rachel Kruzan; Cynthia M Boyd
Journal:  J Am Board Fam Med       Date:  2019 May-Jun       Impact factor: 2.657

6.  Clinical implications of the new diagnostic guidelines for dementia.

Authors:  Edmund Howe
Journal:  Innov Clin Neurosci       Date:  2013-05

7.  Quality improvement in neurology: dementia management quality measures.

Authors:  Germaine Odenheimer; Soo Borson; Amy E Sanders; Rebecca J Swain-Eng; Helen H Kyomen; Samantha Tierney; Laura N Gitlin; Mary Ann Forciea; John Absher; Joseph Shega; Jerry Johnson
Journal:  Neurology       Date:  2013-09-25       Impact factor: 9.910

8.  What are the caregivers' needs on dementia care? An integrated qualitative and quantitative assessment.

Authors:  Ilaria Cova; N Travi; L Maggiore; V Cucumo; C Mariani; S Pomati
Journal:  Neurol Sci       Date:  2018-04-05       Impact factor: 3.307

9.  Testing Tele-Savvy: Protocol for a randomized controlled trial.

Authors:  Mariya A Kovaleva; Elizabeth Bilsborough; Patricia C Griffiths; Joe Nocera; Melinda Higgins; Fayron Epps; Katie Kilgore; Allison Lindauer; Darby Morhardt; Raj C Shah; Kenneth Hepburn
Journal:  Res Nurs Health       Date:  2018-02-05       Impact factor: 2.228

Review 10.  Assessing neuropsychiatric symptoms in people with dementia: a systematic review of measures.

Authors:  Laura N Gitlin; Katherine A Marx; Ian H Stanley; Bryan R Hansen; Kimberly S Van Haitsma
Journal:  Int Psychogeriatr       Date:  2014-08-06       Impact factor: 3.878

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