Literature DB >> 23166050

Intelligent, self-powered, drug delivery systems.

Debabrata Patra1, Samudra Sengupta, Wentao Duan, Hua Zhang, Ryan Pavlick, Ayusman Sen.   

Abstract

Self-propelled nano/micromotors and pumps are considered to be next generation drug delivery systems since the carriers can either propel themselves ("motor"-based drug delivery) or be delivered ("pump"-based drug delivery) to the target in response to specific biomarkers. Recently, there has been significant advancement towards developing nano/microtransporters into proof-of-concept tools for biomedical applications. This review encompasses the progress made to date on the design of synthetic nano/micromotors and pumps with respect to transportation and delivery of cargo at specific locations. Looking ahead, it is possible to imagine a day when intelligent machines navigate through the human body and perform challenging tasks.

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Year:  2013        PMID: 23166050     DOI: 10.1039/c2nr32600k

Source DB:  PubMed          Journal:  Nanoscale        ISSN: 2040-3364            Impact factor:   7.790


  40 in total

1.  Catalytically powered dynamic assembly of rod-shaped nanomotors and passive tracer particles.

Authors:  Wei Wang; Wentao Duan; Ayusman Sen; Thomas E Mallouk
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-14       Impact factor: 11.205

2.  Self-powered enzyme micropumps.

Authors:  Samudra Sengupta; Debabrata Patra; Isamar Ortiz-Rivera; Arjun Agrawal; Sergey Shklyaev; Krishna K Dey; Ubaldo Córdova-Figueroa; Thomas E Mallouk; Ayusman Sen
Journal:  Nat Chem       Date:  2014-03-30       Impact factor: 24.427

3.  Finding efficient swimming strategies in a three-dimensional chaotic flow by reinforcement learning.

Authors:  K Gustavsson; L Biferale; A Celani; S Colabrese
Journal:  Eur Phys J E Soft Matter       Date:  2017-12-14       Impact factor: 1.890

4.  Dynamics of a Protein Chain Motor Driving Helical Bacteria under Stress.

Authors:  Julian Roth; Matthias D Koch; Alexander Rohrbach
Journal:  Biophys J       Date:  2018-04-24       Impact factor: 4.033

5.  Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone.

Authors:  Mohamed Shehata Draz; Nivethitha Kota Lakshminaraasimulu; Sanchana Krishnakumar; Dheerendranath Battalapalli; Anish Vasan; Manoj Kumar Kanakasabapathy; Aparna Sreeram; Shantanu Kallakuri; Prudhvi Thirumalaraju; Yudong Li; Stephane Hua; Xu G Yu; Daniel R Kuritzkes; Hadi Shafiee
Journal:  ACS Nano       Date:  2018-05-16       Impact factor: 15.881

6.  3D Printed Microtransporters: Compound Micromachines for Spatiotemporally Controlled Delivery of Therapeutic Agents.

Authors:  Tian-Yun Huang; Mahmut Selman Sakar; Angelo Mao; Andrew J Petruska; Famin Qiu; Xue-Bo Chen; Stephen Kennedy; David Mooney; Bradley J Nelson
Journal:  Adv Mater       Date:  2015-09-28       Impact factor: 30.849

7.  Bone-crack detection, targeting, and repair using ion gradients.

Authors:  Vinita Yadav; Jonathan D Freedman; Mark Grinstaff; Ayusman Sen
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-26       Impact factor: 15.336

8.  Selectively manipulable acoustic-powered microswimmers.

Authors:  Daniel Ahmed; Mengqian Lu; Amir Nourhani; Paul E Lammert; Zak Stratton; Hari S Muddana; Vincent H Crespi; Tony Jun Huang
Journal:  Sci Rep       Date:  2015-05-20       Impact factor: 4.379

9.  Thermal activation of catalytic microjets in blood samples using microfluidic chips.

Authors:  Lluís Soler; Cynthia Martínez-Cisneros; Anka Swiersy; Samuel Sánchez; Oliver G Schmidt
Journal:  Lab Chip       Date:  2013-11-21       Impact factor: 6.799

10.  Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells.

Authors:  Alessandro Poggi; Silvia Boero; Alessandra Musso; Maria Raffaella Zocchi
Journal:  PLoS One       Date:  2013-05-07       Impact factor: 3.240

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