| Literature DB >> 23164707 |
Libo Xu1, Amy K Farthing, James F Dropinski, Peter T Meinke, Christine McCallum, Emily Hickey, Kun Liu.
Abstract
Semi-synthetic water-soluble analogs were synthesized from nocathiacin I through the formation of a versatile intermediate nocathiacin amine 5, and subsequent transformation via reductive amination, acylation or urea formation. Several of the novel analogs displayed much improved aqueous solubility over 1, while retained antibacterial activity. Compound 15 and 16 from the amide series, demonstrated excellent in vitro and in vivo antibacterial activity.Entities:
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Year: 2012 PMID： 23164707 DOI： 10.1016/j.bmcl.2012.10.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823