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Literature DB >> 23154980

Zebrafish genetics gets the Scube on Hedgehog secretion.

Abstract

Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

Entities: Gene Species

Year: 2012 PMID： 23154980 PMCID： PMC3505816 DOI： 10.1101/gad.207126.112

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

16 in total

1. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.

Authors: Adrian Creanga; Thomas D Glenn; Randall K Mann; Adam M Saunders; William S Talbot; Philip A Beachy
Journal: Genes Dev Date: 2012-06-07 Impact factor: 11.361

2. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia.

Authors: Armel Gallet; Laurent Ruel; Laurence Staccini-Lavenant; Pascal P Thérond
Journal: Development Date: 2006-01-05 Impact factor: 6.868

3. Scube2 mediates Hedgehog signalling in the zebrafish embryo.

Authors: Georgina E Hollway; John Maule; Philippe Gautier; Timothy M Evans; David G Keenan; Claudia Lohs; Danielle Fischer; Carol Wicking; Peter D Currie
Journal: Dev Biol Date: 2006-04-13 Impact factor: 3.582

4. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.

Authors: R Burke; D Nellen; M Bellotto; E Hafen; K A Senti; B J Dickson; K Basler
Journal: Cell Date: 1999-12-23 Impact factor: 41.582

5. Identification of a palmitic acid-modified form of human Sonic hedgehog.

Authors: R B Pepinsky; C Zeng; D Wen; P Rayhorn; D P Baker; K P Williams; S A Bixler; C M Ambrose; E A Garber; K Miatkowski; F R Taylor; E A Wang; A Galdes
Journal: J Biol Chem Date: 1998-05-29 Impact factor: 5.157

6. A freely diffusible form of Sonic hedgehog mediates long-range signalling.

Authors: X Zeng; J A Goetz; L M Suber; W J Scott; C M Schreiner; D J Robbins
Journal: Nature Date: 2001-06-07 Impact factor: 49.962

7. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

Authors: P M Lewis; M P Dunn; J A McMahon; M Logan; J F Martin; B St-Jacques; A P McMahon
Journal: Cell Date: 2001-06-01 Impact factor: 41.582

8. Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.

Authors: S Grimmond; R Larder; N Van Hateren; P Siggers; S Morse; T Hacker; R Arkell; A Greenfield
Journal: Mech Dev Date: 2001-04 Impact factor: 1.882

9. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.

Authors: Atsushi Kawakami; Yasuhiro Nojima; Atsushi Toyoda; Mikako Takahoko; Miki Satoh; Hideomi Tanaka; Hironori Wada; Ichiro Masai; Harumi Terasaki; Yoshiyuki Sakaki; Hiroyuki Takeda; Hitoshi Okamoto
Journal: Curr Biol Date: 2005-03-08 Impact factor: 10.834

10. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.

Authors: F J van Eeden; M Granato; U Schach; M Brand; M Furutani-Seiki; P Haffter; M Hammerschmidt; C P Heisenberg; Y J Jiang; D A Kane; R N Kelsh; M C Mullins; J Odenthal; R M Warga; M L Allende; E S Weinberg; C Nüsslein-Volhard
Journal: Development Date: 1996-12 Impact factor: 6.868

1 in total

Review 1. Lipid metabolism fattens up hedgehog signaling.

Authors: Robert Blassberg; John Jacob
Journal: BMC Biol Date: 2017-10-26 Impact factor: 7.431

1 in total