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Literature DB >> 11287194

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.

S Grimmond¹, R Larder, N Van Hateren, P Siggers, S Morse, T Hacker, R Arkell, A Greenfield.

Abstract

We have recently reported the preliminary characterisation of a novel EGF-related gene, Scube1 (signal peptide-CUB domain-EGF-related, gene 1), that is expressed prominently in the developing gonad, nervous system, somites, surface ectoderm and limb buds of the mouse. Here we describe the expression pattern of a closely related gene, Scube2 (also known as Cegp1), which maps to the distal region of mouse chromosome 7. Scube2 transcription is restricted to the embryonic neurectoderm but is also detectable in the adult heart, lung and testis.

Entities: Gene Species

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Year: 2001 PMID： 11287194 DOI： 10.1016/s0925-4773(00)00586-4

Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882

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Cited

11 in total

1. The mouse secretome: functional classification of the proteins secreted into the extracellular environment.

Authors: Sean M Grimmond; Kevin C Miranda; Zheng Yuan; Melissa J Davis; David A Hume; Ken Yagi; Naoko Tominaga; Hidemasa Bono; Yoshihide Hayashizaki; Yasushi Okazaki; Rohan D Teasdale
Journal: Genome Res Date: 2003-06 Impact factor: 9.043

2. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.

Authors: Adrian Creanga; Thomas D Glenn; Randall K Mann; Adam M Saunders; William S Talbot; Philip A Beachy
Journal: Genes Dev Date: 2012-06-07 Impact factor: 11.361

3. Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis.

Authors: Ku-Chi Tsao; Cheng-Fen Tu; Shyh-Jye Lee; Ruey-Bing Yang
Journal: J Biol Chem Date: 2012-12-27 Impact factor: 5.157

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.

1. The mouse secretome: functional classification of the proteins secreted into the extracellular environment.

2. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.

3. Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis.

4. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.

5. Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand.

6. Scube2 expression extends beyond the central nervous system during mouse development.

7. Zebrafish genetics gets the Scube on Hedgehog secretion.

8. The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish.

9. Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.

10. Circulating SCUBE1 levels in women with polycystic ovary syndrome.