BACKGROUND AND PURPOSE: The relationship between aneurysm dimensions, flow, thrombosis, and rupture remains poorly understood. We attempted to clarify this relationship by exploring various swine aneurysm models. MATERIALS AND METHODS: Bilateral carotid aneurysms were constructed according to 3 protocols in 24 animals: small aneurysms with wide necks (group 1; n = 6 animals); small aneurysms with small necks (group 2; n = 4 animals), and giant aneurysms with large necks (group 3; n = 14 animals). Group 3 included 3 subgroups, related to testing the model in various experimental conditions: The neck was clipped in 3 animals; venous pouches lacked an endothelial lining in 4 animals; and 7 were control animals. Animals were followed until rupture, or for 1-4 weeks. Angiography was performed postoperatively and before euthanasia. We studied lesion pathology, paying attention to thrombosis, recanalization, wall composition, and perianeurysmal hemorrhage. RESULTS: Groups differed significantly in aneurysm dimensions and aspect ratio (P = .002). Ruptures occurred more frequently in animals with untreated giant aneurysms (7/7) than in animals with small wide-neck (0/6) or small-neck (2/4) aneurysms (P = .002). Ruptures occurred only in animals with thrombosed aneurysms. Lesions lacking an endothelial lining and 5 of 6 clipped venous pouches thrombosed but did not rupture. One giant lesion ruptured despite complete clipping. The wall was deficient in α-actin and was infiltrated with inflammatory cells and erythrocytes in all thrombosed cases, ruptured or not. Ruptures were associated with recanalizing channels in 9 of 10 cases. CONCLUSIONS: Thrombosis, inflammation, and recanalization may precipitate aneurysmal ruptures in a swine model.
BACKGROUND AND PURPOSE: The relationship between aneurysm dimensions, flow, thrombosis, and rupture remains poorly understood. We attempted to clarify this relationship by exploring various swineaneurysm models. MATERIALS AND METHODS: Bilateral carotid aneurysms were constructed according to 3 protocols in 24 animals: small aneurysms with wide necks (group 1; n = 6 animals); small aneurysms with small necks (group 2; n = 4 animals), and giant aneurysms with large necks (group 3; n = 14 animals). Group 3 included 3 subgroups, related to testing the model in various experimental conditions: The neck was clipped in 3 animals; venous pouches lacked an endothelial lining in 4 animals; and 7 were control animals. Animals were followed until rupture, or for 1-4 weeks. Angiography was performed postoperatively and before euthanasia. We studied lesion pathology, paying attention to thrombosis, recanalization, wall composition, and perianeurysmal hemorrhage. RESULTS: Groups differed significantly in aneurysm dimensions and aspect ratio (P = .002). Ruptures occurred more frequently in animals with untreated giant aneurysms (7/7) than in animals with small wide-neck (0/6) or small-neck (2/4) aneurysms (P = .002). Ruptures occurred only in animals with thrombosed aneurysms. Lesions lacking an endothelial lining and 5 of 6 clipped venous pouches thrombosed but did not rupture. One giant lesion ruptured despite complete clipping. The wall was deficient in α-actin and was infiltrated with inflammatory cells and erythrocytes in all thrombosed cases, ruptured or not. Ruptures were associated with recanalizing channels in 9 of 10 cases. CONCLUSIONS:Thrombosis, inflammation, and recanalization may precipitate aneurysmal ruptures in a swine model.
Authors: A S Turk; B Aagaard-Kienitz; D Niemann; D Consigny; A Rappe; J Grinde; C M Strother Journal: AJNR Am J Neuroradiol Date: 2007-03 Impact factor: 3.825
Authors: H Ujiie; H Tachibana; O Hiramatsu; A L Hazel; T Matsumoto; Y Ogasawara; H Nakajima; T Hori; K Takakura; F Kajiya Journal: Neurosurgery Date: 1999-07 Impact factor: 4.654
Authors: R Kadirvel; D Dai; Y H Ding; M A Danielson; D A Lewis; H J Cloft; D F Kallmes Journal: AJNR Am J Neuroradiol Date: 2007-05 Impact factor: 3.825
Authors: Robert Fahed; Tim E Darsaut; Jean-Christophe Gentric; Behzad Farzin; Igor Salazkin; Guylaine Gevry; Jean Raymond Journal: Neuroradiology Date: 2017-02-27 Impact factor: 2.804
Authors: M J Gounis; I M J van der Bom; A K Wakhloo; S Zheng; J-Y Chueh; A L Kühn; A A Bogdanov Journal: AJNR Am J Neuroradiol Date: 2014-10-01 Impact factor: 3.825
Authors: Robert Fahed; Jean Raymond; Célina Ducroux; Jean-Christophe Gentric; Igor Salazkin; Daniela Ziegler; Guylaine Gevry; Tim E Darsaut Journal: Neuroradiology Date: 2016-01-08 Impact factor: 2.804
Authors: T E Darsaut; E Rayner-Hartley; A Makoyeva; I Salazkin; F Berthelet; J Raymond Journal: Interv Neuroradiol Date: 2013-05-21 Impact factor: 1.610