Literature DB >> 23151875

Injecting epidural and intra-articular triamcinolone in HIV-positive patients on ritonavir: beware of iatrogenic Cushing's syndrome.

M Maviki1, P Cowley, H Marmery.   

Abstract

We report two HIV-positive patients on highly active antiretroviral therapy (HAART) who developed clinical features in keeping with secondary adrenal suppression following epidural and subacromial triamcinolone. Both patients were on ritonavir-boosted protease inhibitor containing HAART and both required maintenance hydrocortisone therapy following diagnosis. This highlights the need for radiologists and clinicians practicing these injections to be aware of this complication, to elicit an accurate drug history, and to take adequate measures to minimize these adverse effects.

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Year:  2012        PMID: 23151875     DOI: 10.1007/s00256-012-1539-6

Source DB:  PubMed          Journal:  Skeletal Radiol        ISSN: 0364-2348            Impact factor:   2.199


  6 in total

1.  Ritonavir and epidural triamcinolone as a cause of iatrogenic Cushing's syndrome.

Authors:  Nicole E Albert; Saifullah Kazi; Jerome Santoro; Rebecca Dougherty
Journal:  Am J Med Sci       Date:  2012-07       Impact factor: 2.378

2.  Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

Authors:  Roshan Ramanathan; Alice K Pau; Kristin H Busse; Marina Zemskova; Lynnette Nieman; Richard Kwan; Jean H Hammer; JoAnn M Mican; Frank Maldarelli
Journal:  Clin Infect Dis       Date:  2008-12-15       Impact factor: 9.079

3.  Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent.

Authors:  Renee M St Germain; Sevket Yigit; Lorraine Wells; Jennifer E Girotto; Jennifer E Giratto; Juan C Salazar
Journal:  AIDS Patient Care STDS       Date:  2007-06       Impact factor: 5.078

4.  Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration.

Authors:  H Derendorf; H Möllmann; A Grüner; D Haack; G Gyselby
Journal:  Clin Pharmacol Ther       Date:  1986-03       Impact factor: 6.875

5.  Metabolic derangement after injection of triamcinolone into the hip of an HIV-infected patient receiving ritonavir.

Authors:  Patrick J Danaher; Thomas L Salsbury; Judith A Delmar
Journal:  Orthopedics       Date:  2009-06       Impact factor: 1.390

6.  Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report.

Authors:  Kathryn Dort; Shetal Padia; Brian Wispelwey; Christopher C Moore
Journal:  AIDS Res Ther       Date:  2009-06-08       Impact factor: 2.250

  6 in total
  7 in total

1.  Exogenous steroid-induced hypoadrenalism in a person living with HIV caused by a drug-drug interaction between cobicistat and intrabursal triamcinolone.

Authors:  Navnit Makaram; Clark D Russell; Simon Benedict Roberts; Jarrad Stevens; Gavin Macpherson
Journal:  BMJ Case Rep       Date:  2018-12-14

Review 2.  Intra-articular glucocorticoid injections and their effect on hypothalamic-pituitary-adrenal (HPA)-axis function.

Authors:  Philip C Johnston; M Cecilia Lansang; Soumya Chatterjee; Laurence Kennedy
Journal:  Endocrine       Date:  2014-09-03       Impact factor: 3.633

3.  Triamcinolone and ritonavir leading to drug-induced Cushing syndrome and adrenal suppression: description of a new case and review of the literature.

Authors:  C Schwarze-Zander; D Klingmüller; J Klümper; C P Strassburg; J K Rockstroh
Journal:  Infection       Date:  2013-07-20       Impact factor: 3.553

Review 4.  Iatrogenic cushing syndrome secondary to ritonavir-epidural triamcinolone interaction: an illustrative case and review.

Authors:  Sapna Sadarangani; Melody L Berg; William Mauck; Stacey Rizza
Journal:  Interdiscip Perspect Infect Dis       Date:  2014-05-07

5.  Iatrogenic Cushing's Syndrome Following Intra-Articular Triamcinolone Injection in an HIV-Infected Patient on Cobicistat Presenting as a Pulmonary Embolism: Case Report and Literature Review.

Authors:  Marjan Alidoost; Gabriella A Conte; Khushboo Agarwal; Michael P Carson; Danielle Lann; Diane Marchesani
Journal:  Int Med Case Rep J       Date:  2020-06-09

Review 6.  Complications in image-guided musculoskeletal injections.

Authors:  John P Hynes; Eoin C Kavanagh
Journal:  Skeletal Radiol       Date:  2022-05-27       Impact factor: 2.128

7.  Acute development of Cushing syndrome in an HIV-infected child on atazanavir/ritonavir based antiretroviral therapy.

Authors:  Gueorgui Dubrocq; Andrea Estrada; Shannon Kelly; Natella Rakhmanina
Journal:  Endocrinol Diabetes Metab Case Rep       Date:  2017-10-28
  7 in total

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