Literature DB >> 18991509

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

Roshan Ramanathan1, Alice K Pau, Kristin H Busse, Marina Zemskova, Lynnette Nieman, Richard Kwan, Jean H Hammer, JoAnn M Mican, Frank Maldarelli.   

Abstract

We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid.

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Year:  2008        PMID： 18991509      PMCID： PMC2941349          DOI： 10.1086/593314

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  11 in total

1.  Secondary Cushing's syndrome after a single epidural injection of a corticosteroid.

Authors:  Mohamad Hosam Horani; Alan B Silverberg
Journal:  Endocr Pract       Date:  2005 Nov-Dec       Impact factor: 3.443

2.  The quantification of cytochrome P-450 (CYP 3A4) mRNA in the blood of patients with viral liver diseases.

Authors:  Norio Horiike; Masanori Abe; Teru Kumagi; Yoichi Hiasa; S M Fazle Akbar; Kojiro Michitaka; Morikazu Onji
Journal:  Clin Biochem       Date:  2005-06       Impact factor: 3.281

3.  Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers.

Authors:  Scott R Penzak; Elizabeth Formentini; Raul M Alfaro; Michael Long; Ven Natarajan; Joseph Kovacs
Journal:  J Acquir Immune Defic Syndr       Date:  2005-12-15       Impact factor: 3.731

4.  Mechanisms of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone and dexamethasone on in vitro expression of lymphocyte function.

Authors:  A S Fauci
Journal:  Clin Exp Immunol       Date:  1976-04       Impact factor: 4.330

5.  Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virus-infected patients receiving inhaled corticosteroids and ritonavir-boosted protease inhibitors: six cases.

Authors:  Katherine Samaras; Sarah Pett; Andrew Gowers; Marilyn McMurchie; David A Cooper
Journal:  J Clin Endocrinol Metab       Date:  2005-03-08       Impact factor: 5.958

6.  Nasal mucosal inflammation has no effect on the absorption of intranasal triamcinolone acetonide.

Authors:  D Argenti; I Colligon; D Heald; J Ziemniak
Journal:  J Clin Pharmacol       Date:  1994-08       Impact factor: 3.126

7.  Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.

Authors:  James L Weemhoff; Lisa L von Moltke; Clemens Richert; Leah M Hesse; Jerold S Harmatz; David J Greenblatt
Journal:  J Pharm Pharmacol       Date:  2003-03       Impact factor: 3.765

8.  Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration.

Authors:  H Derendorf; H Möllmann; A Grüner; D Haack; G Gyselby
Journal:  Clin Pharmacol Ther       Date:  1986-03       Impact factor: 6.875

9.  Progression of Kaposi sarcoma associated with iatrogenic Cushing syndrome in a person with HIV/AIDS.

Authors:  Sadao Jinno; Cyril Goshima
Journal:  AIDS Read       Date:  2008-02

Review 10.  Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.

Authors:  Shu-Feng Zhou; Charlie Changli Xue; Xue-Qing Yu; Chunguang Li; Guangji Wang
Journal:  Ther Drug Monit       Date:  2007-12       Impact factor: 3.681
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  12 in total

1.  Exogenous steroid-induced hypoadrenalism in a person living with HIV caused by a drug-drug interaction between cobicistat and intrabursal triamcinolone.

Authors:  Navnit Makaram; Clark D Russell; Simon Benedict Roberts; Jarrad Stevens; Gavin Macpherson
Journal:  BMJ Case Rep       Date:  2018-12-14

Review 2.  The skeletal consequences of epidural steroid injections: a literature review.

Authors:  A Krez; Y Liu; S Kanbour; S Clare; S Waldman; E M Stein
Journal:  Osteoporos Int       Date:  2021-06-04       Impact factor: 4.507

3.  Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1.

Authors:  Hannah Zelie Ruth McConkey; Helen Williams; Ranjababu Kulasegaram; Elizabeth Graham
Journal:  BMJ Case Rep       Date:  2013-02-25

4.  Injecting epidural and intra-articular triamcinolone in HIV-positive patients on ritonavir: beware of iatrogenic Cushing's syndrome.

Authors:  M Maviki; P Cowley; H Marmery
Journal:  Skeletal Radiol       Date:  2012-11-15       Impact factor: 2.199

5.  Important Drug-Drug Interactions in HIV-Infected Persons on Antiretroviral Therapy: An Update on New Interactions Between HIV and Non-HIV Drugs.

Authors:  Alice Tseng; Michelle Foisy
Journal:  Curr Infect Dis Rep       Date:  2012-02       Impact factor: 3.725

6.  Recognition and management of significant drug interactions in HIV patients: challenges in using available data to guide therapy.

Authors:  A K Pau; S D Boyd
Journal:  Clin Pharmacol Ther       Date:  2010-07-28       Impact factor: 6.875

7.  RAPID DEVELOPMENT OF IATROGENIC CUSHING SYNDROME IN A PATIENT ON RITONAVIR: THE ADVERSE METABOLIC CONSEQUENCE OF TOPICAL STEROID USE.

Authors:  Jeremy D Purser; Ruba Riachy; Lucas S Blanton; L Maria Belalcazar
Journal:  AACE Clin Case Rep       Date:  2020-09-24

8.  High frequency of hypothalamic-pituitary-adrenal axis dysfunction after local corticosteroid injection in HIV-infected patients on protease inhibitor therapy.

Authors:  Emily P Hyle; Brian R Wood; Elke S Backman; Farzad Noubary; Janice Hwang; Zhigang Lu; Elena Losina; Rochelle P Walensky; Rajesh T Gandhi
Journal:  J Acquir Immune Defic Syndr       Date:  2013-08-15       Impact factor: 3.731

9.  Triamcinolone and ritonavir leading to drug-induced Cushing syndrome and adrenal suppression: description of a new case and review of the literature.

Authors:  C Schwarze-Zander; D Klingmüller; J Klümper; C P Strassburg; J K Rockstroh
Journal:  Infection       Date:  2013-07-20       Impact factor: 3.553

10.  Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report.

Authors:  Kathryn Dort; Shetal Padia; Brian Wispelwey; Christopher C Moore
Journal:  AIDS Res Ther       Date:  2009-06-08       Impact factor: 2.250
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