BACKGROUND: Patients with congenital diaphragmatic hernia (CDH) may have abnormal lung development, which may cause detrimental effects on right ventricular (RV) function. This study aimed to determine if there are persistent echocardiographic differences in RV function in patients with CDH years after repair versus control patients. METHODS: Patients who underwent repair for CDH were recruited. RV function was evaluated by strain analysis and tissue Doppler imaging (TDI). Wilcoxon's rank-sum test was used for analysis. RESULTS: Seven CDH patients and 16 control patients were studied. There was no difference in age between the CDH and control groups (6.2±1.7 years vs. 5.7±1.7 years). TDI demonstrated significantly lower values in the RV early diastolic wave (12.8±1.5 cm/s vs. 16.1±3.1 cm/s) and RV systolic wave (10.2± 0.8cm/s vs. 13.4±1.3 cm/s) when comparing the CDH group and the control group. Interventricular apical septal strain was signifi cantly lower in the CDH group than in the control group (-20.1±4.6% vs. -25.4±4.1%). There was a trend towards lower strain values in the RV mid-lateral segment in the CDH group (-30.8±9.9% versus -39.7±6.0%, P=0.06) and a lower global RV strain (-27.8±3.0% vs. -31.1±3.1%, P=0.06). CONCLUSIONS: Patients who underwent CDH repair continue to have differences in RV function years after repair. Follow-up is needed to determine how these differences impact cardiac function in adult survivors of CDH.
BACKGROUND:Patients with congenital diaphragmatic hernia (CDH) may have abnormal lung development, which may cause detrimental effects on right ventricular (RV) function. This study aimed to determine if there are persistent echocardiographic differences in RV function in patients with CDH years after repair versus control patients. METHODS:Patients who underwent repair for CDH were recruited. RV function was evaluated by strain analysis and tissue Doppler imaging (TDI). Wilcoxon's rank-sum test was used for analysis. RESULTS: Seven CDH patients and 16 control patients were studied. There was no difference in age between the CDH and control groups (6.2±1.7 years vs. 5.7±1.7 years). TDI demonstrated significantly lower values in the RV early diastolic wave (12.8±1.5 cm/s vs. 16.1±3.1 cm/s) and RV systolic wave (10.2± 0.8cm/s vs. 13.4±1.3 cm/s) when comparing the CDH group and the control group. Interventricular apical septal strain was signifi cantly lower in the CDH group than in the control group (-20.1±4.6% vs. -25.4±4.1%). There was a trend towards lower strain values in the RV mid-lateral segment in the CDH group (-30.8±9.9% versus -39.7±6.0%, P=0.06) and a lower global RV strain (-27.8±3.0% vs. -31.1±3.1%, P=0.06). CONCLUSIONS:Patients who underwent CDH repair continue to have differences in RV function years after repair. Follow-up is needed to determine how these differences impact cardiac function in adult survivors of CDH.
Authors: Arthur Filusch; Derliz Mereles; Ekkehard Gruenig; Sebastian Buss; Hugo A Katus; F Joachim Meyer Journal: Clin Res Cardiol Date: 2010-03-30 Impact factor: 5.460
Authors: A A Ionescu; A A Ionescu; N Payne; I Obieta-Fresnedo; A G Fraser; D J Shale Journal: Am J Respir Crit Care Med Date: 2001-04 Impact factor: 21.405
Authors: Nasser Moiduddin; Karen M Texter; Ali N Zaidi; Jared A Hershenson; Carol A Stefaniak; John Hayes; Clifford L Cua Journal: J Am Soc Echocardiogr Date: 2010-04-21 Impact factor: 5.251
Authors: Maria João Baptista; Cristina Nogueira-Silva; José Carlos Areias; Jorge Correia-Pinto Journal: J Pediatr Surg Date: 2008-04 Impact factor: 2.545
Authors: M G Peetsold; H A Heij; C M F Kneepkens; A F Nagelkerke; J Huisman; R J B J Gemke Journal: Pediatr Surg Int Date: 2008-10-08 Impact factor: 1.827
Authors: P H Manso; R L Figueira; C M Prado; F L Gonçalves; A L B Simões; S G Ramos; L Sbragia Journal: Braz J Med Biol Res Date: 2015-02-03 Impact factor: 2.590
Authors: Catherine M Avitabile; Yan Wang; Xuemei Zhang; Heather Griffis; Sofia Saavedra; Samantha Adams; Lisa Herkert; David B Frank; Michael D Quartermain; Natalie E Rintoul; Holly L Hedrick; Laura Mercer-Rosa Journal: Ann Am Thorac Soc Date: 2020-11