Literature DB >> 23151581

Metabolic phenotyping in clinical and surgical environments.

Jeremy K Nicholson1, Elaine Holmes, James M Kinross, Ara W Darzi, Zoltan Takats, John C Lindon.   

Abstract

Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's physiological or pathological states that relate to disease diagnosis or prognosis at the individual level and to disease risk factors at the population level. These approaches are currently being implemented in hospital environments and in regional phenotyping centres worldwide. The ultimate aim of such work is to generate information on patient biology using techniques such as patient stratification to better inform clinicians on factors that will enhance diagnosis or the choice of therapy. There have been many reports of direct applications of metabolic phenotyping in a clinical setting.

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Year:  2012        PMID: 23151581     DOI: 10.1038/nature11708

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  100 in total

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Journal:  J Am Soc Mass Spectrom       Date:  2011-09-03       Impact factor: 3.109

Review 2.  Metabolomics as a tool for cardiac research.

Authors:  Julian L Griffin; Helen Atherton; John Shockcor; Luigi Atzori
Journal:  Nat Rev Cardiol       Date:  2011-09-20       Impact factor: 32.419

Review 3.  Host-gut microbiota metabolic interactions.

Authors:  Jeremy K Nicholson; Elaine Holmes; James Kinross; Remy Burcelin; Glenn Gibson; Wei Jia; Sven Pettersson
Journal:  Science       Date:  2012-06-06       Impact factor: 47.728

4.  Cross-platform analysis of longitudinal data in metabolomics.

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Journal:  Mol Biosyst       Date:  2011-09-22

5.  Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine.

Authors:  Joana Carrola; Cláudia M Rocha; António S Barros; Ana M Gil; Brian J Goodfellow; Isabel M Carreira; João Bernardo; Ana Gomes; Vitor Sousa; Lina Carvalho; Iola F Duarte
Journal:  J Proteome Res       Date:  2010-11-23       Impact factor: 4.466

6.  Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: a pilot study.

Authors:  Leonardo Tenori; Catherine Oakman; Wederson M Claudino; Patrizia Bernini; Silvia Cappadona; Stefano Nepi; Laura Biganzoli; Michael C Arbushites; Claudio Luchinat; Ivano Bertini; Angelo Di Leo
Journal:  Mol Oncol       Date:  2012-06-01       Impact factor: 6.603

7.  GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis.

Authors:  Makoto Ooi; Shin Nishiumi; Tomoo Yoshie; Yuuki Shiomi; Michitaka Kohashi; Ken Fukunaga; Shiro Nakamura; Takayuki Matsumoto; Naoya Hatano; Masakazu Shinohara; Yasuhiro Irino; Tadaomi Takenawa; Takeshi Azuma; Masaru Yoshida
Journal:  Inflamm Res       Date:  2011-04-27       Impact factor: 4.575

8.  Symbiotic gut microbes modulate human metabolic phenotypes.

Authors:  Min Li; Baohong Wang; Menghui Zhang; Mattias Rantalainen; Shengyue Wang; Haokui Zhou; Yan Zhang; Jian Shen; Xiaoyan Pang; Meiling Zhang; Hua Wei; Yu Chen; Haifeng Lu; Jian Zuo; Mingming Su; Yunping Qiu; Wei Jia; Chaoni Xiao; Leon M Smith; Shengli Yang; Elaine Holmes; Huiru Tang; Guoping Zhao; Jeremy K Nicholson; Lanjuan Li; Liping Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-05       Impact factor: 11.205

Review 9.  Aging of the human metaorganism: the microbial counterpart.

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Journal:  Age (Dordr)       Date:  2011-02-24

10.  A novel serum metabolomics-based diagnostic approach for colorectal cancer.

Authors:  Shin Nishiumi; Takashi Kobayashi; Atsuki Ikeda; Tomoo Yoshie; Megumi Kibi; Yoshihiro Izumi; Tatsuya Okuno; Nobuhide Hayashi; Seiji Kawano; Tadaomi Takenawa; Takeshi Azuma; Masaru Yoshida
Journal:  PLoS One       Date:  2012-07-11       Impact factor: 3.240

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  161 in total

1.  Combining NMR and LC/MS Using Backward Variable Elimination: Metabolomics Analysis of Colorectal Cancer, Polyps, and Healthy Controls.

Authors:  Lingli Deng; Haiwei Gu; Jiangjiang Zhu; G A Nagana Gowda; Danijel Djukovic; E Gabriela Chiorean; Daniel Raftery
Journal:  Anal Chem       Date:  2016-08-01       Impact factor: 6.986

Review 2.  Expression and Metabolomic Profiling in Axial Spondyloarthritis.

Authors:  Darren D O'Rielly; Guangju Zhai; Proton Rahman
Journal:  Curr Rheumatol Rep       Date:  2018-06-27       Impact factor: 4.592

3.  Real-time lipid patterns to classify viable and necrotic liver tumors.

Authors:  Pierre-Maxence Vaysse; Heike I Grabsch; Mari F C M van den Hout; Marc H A Bemelmans; Ron M A Heeren; Steven W M Olde Damink; Tiffany Porta Siegel
Journal:  Lab Invest       Date:  2021-01-22       Impact factor: 5.662

4.  Metabolomics technology and bioinformatics for precision medicine.

Authors:  Rajeev K Azad; Vladimir Shulaev
Journal:  Brief Bioinform       Date:  2019-11-27       Impact factor: 11.622

5.  Malignancy prediction among tissues from Oral SCC patients including neck invasions: a 1H HRMAS NMR based metabolomic study.

Authors:  Anup Paul; Shatakshi Srivastava; Raja Roy; Akshay Anand; Kushagra Gaurav; Nuzhat Husain; Sudha Jain; Abhinav A Sonkar
Journal:  Metabolomics       Date:  2020-03-11       Impact factor: 4.290

6.  Real-Time Pure Shift HSQC NMR for Untargeted Metabolomics.

Authors:  István Timári; Cheng Wang; Alexandar L Hansen; Gilson Costa Dos Santos; Sung Ok Yoon; Lei Bruschweiler-Li; Rafael Brüschweiler
Journal:  Anal Chem       Date:  2019-01-16       Impact factor: 6.986

7.  Exploring Metabolic Profile Differences between Colorectal Polyp Patients and Controls Using Seemingly Unrelated Regression.

Authors:  Chen Chen; Lingli Deng; Siwei Wei; G A Nagana Gowda; Haiwei Gu; Elena G Chiorean; Mohammad Abu Zaid; Marietta L Harrison; Joseph F Pekny; Patrick J Loehrer; Dabao Zhang; Min Zhang; Daniel Raftery
Journal:  J Proteome Res       Date:  2015-05-13       Impact factor: 4.466

8.  Nutriome-metabolome relationships provide insights into dietary intake and metabolism.

Authors:  Joram M Posma; Isabel Garcia-Perez; Gary Frost; Ghadeer S Aljuraiban; Queenie Chan; Linda Van Horn; Martha Daviglus; Jeremiah Stamler; Elaine Holmes; Paul Elliott; Jeremy K Nicholson
Journal:  Nat Food       Date:  2020-06-22

Review 9.  Cerebrospinal fluid analysis in Alzheimer's disease: technical issues and future developments.

Authors:  Simone Lista; Henrik Zetterberg; Bruno Dubois; Kaj Blennow; Harald Hampel
Journal:  J Neurol       Date:  2014-05-08       Impact factor: 4.849

10.  Globally Optimized Targeted Mass Spectrometry: Reliable Metabolomics Analysis with Broad Coverage.

Authors:  Haiwei Gu; Ping Zhang; Jiangjiang Zhu; Daniel Raftery
Journal:  Anal Chem       Date:  2015-12-02       Impact factor: 6.986

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