| Literature DB >> 23150886 |
Isabel P Kerschgens1, Elise Claveau, Martin J Wanner, Steen Ingemann, Jan H van Maarseveen, Henk Hiemstra.
Abstract
The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providing the tetrahydro-β-carboline ring and (ii) a Pd-catalysed Tsuji-Trost allylic alkylation, closing the D-ring.Entities:
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Year: 2012 PMID： 23150886 DOI： 10.1039/c2cc37023a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222