Literature DB >> 23146430

Formulations for trans-tympanic antibiotic delivery.

Xiaojuan Khoo1, Emmanuel J Simons, Homer H Chiang, Julia M Hickey, Vishakha Sabharwal, Stephen I Pelton, John J Rosowski, Robert Langer, Daniel S Kohane.   

Abstract

We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23146430      PMCID： PMC3511665          DOI： 10.1016/j.biomaterials.2012.10.025

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  49 in total

1.  Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis.

Authors:  H Tang; S Mitragotri; D Blankschtein; R Langer
Journal:  J Pharm Sci       Date:  2001-05       Impact factor: 3.534

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Journal:  AMA Arch Otolaryngol       Date:  1957-10

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Journal:  Science       Date:  1990-09-28       Impact factor: 47.728

4.  Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate.

Authors:  Renata F V Lopez; Jennifer E Seto; Daniel Blankschtein; Robert Langer
Journal:  Biomaterials       Date:  2010-10-23       Impact factor: 12.479

Review 5.  Chemical enhancers for transdermal drug transport.

Authors:  K Bauerová; D Matusová; Z Kassai
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2001 Jan-Jun       Impact factor: 2.441

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7.  Tetracaine topical anesthesia for myringotomy.

Authors:  R A Hoffman; C L Li
Journal:  Laryngoscope       Date:  2001-09       Impact factor: 3.325

8.  Exchange rates of gases across the tympanic membrane in rhesus monkeys.

Authors:  W J Doyle; C M Alper; J T Seroky; W J Karnavas
Journal:  Acta Otolaryngol       Date:  1998-07       Impact factor: 1.494

9.  Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin.

Authors:  Hye Sun Gwak; Seung Ung Kim; In Koo Chun
Journal:  Arch Pharm Res       Date:  2002-06       Impact factor: 4.946

Review 10.  Ambulatory health care visits by children: principal diagnosis and place of visit.

Authors:  V M Freid; D M Makuc; R N Rooks
Journal:  Vital Health Stat 13       Date:  1998-05
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  17 in total

1.  Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea.

Authors:  Woo Seok Kang; Shuting Sun; Kim Nguyen; Boris Kashemirov; Charles E McKenna; S Adam Hacking; Alicia M Quesnel; William F Sewell; Michael J McKenna; David H Jung
Journal:  Otol Neurotol       Date:  2015-07       Impact factor: 2.311

Review 2.  Getting Drugs Across Biological Barriers.

Authors:  Rong Yang; Tuo Wei; Hannah Goldberg; Weiping Wang; Kathleen Cullion; Daniel S Kohane
Journal:  Adv Mater       Date:  2017-07-28       Impact factor: 30.849

3.  Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media.

Authors:  Rong Yang; Riitta Saarinen; Obiajulu S Okonkwo; Yi Hao; Manisha Mehta; Daniel S Kohane
Journal:  Mol Pharm       Date:  2019-03-06       Impact factor: 4.939

4.  Biocoating-A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles.

Authors:  Aharon Azagury; Cameron Baptista; Kosta Milovanovic; Hyeseon Shin; Peter Morello; James Perez-Rogers; Victoria Goldenshtein; Travis Nguyen; Arianna Markel; Soham Rege; Stephanie Hojsak; Alexander Perl; Carder Jones; Megan Fife; Stacia Furtado; Edith Mathiowitz
Journal:  Small       Date:  2022-05-23       Impact factor: 15.153

5.  Treatment of otitis media by transtympanic delivery of antibiotics.

Authors:  Rong Yang; Vishakha Sabharwal; Obiajulu S Okonkwo; Nadya Shlykova; Rong Tong; Lily Yun Lin; Weiping Wang; Shutao Guo; John J Rosowski; Stephen I Pelton; Daniel S Kohane
Journal:  Sci Transl Med       Date:  2016-09-14       Impact factor: 17.956

6.  Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics.

Authors:  Rong Yang; Vishakha Sabharwal; Nadya Shlykova; Obiajulu S Okonkwo; Stephen I Pelton; Daniel S Kohane
Journal:  JCI Insight       Date:  2018-10-04

7.  Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker.

Authors:  Wei Li; Jared J Hartsock; Chunfu Dai; Alec N Salt
Journal:  Otol Neurotol       Date:  2018-06       Impact factor: 2.311

8.  Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane.

Authors:  Rong Yang; Obiajulu S Okonkwo; David Zurakowski; Daniel S Kohane
Journal:  J Control Release       Date:  2018-06-19       Impact factor: 9.776

9.  Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception.

Authors:  Pin-Chieh Huang; Eric J Chaney; Ryan L Shelton; Stephen A Boppart
Journal:  IEEE Trans Biomed Eng       Date:  2018-03-26       Impact factor: 4.538

10.  Teprotumumab-associated chronic hearing loss screening and proposed treatments.

Authors:  Audrey Chow; Rona Z Silkiss
Journal:  BMJ Case Rep       Date:  2022-04-13
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