Literature DB >> 23146254

Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study.

George Bush1, Jennifer Holmes, Lisa M Shin, Craig Surman, Nikos Makris, Eric Mick, Larry J Seidman, Joseph Biederman.   

Abstract

We hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID： 23146254      PMCID： PMC3557757          DOI： 10.1016/j.pscychresns.2012.09.004

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  24 in total

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Journal:  Psychopharmacology (Berl)       Date:  2006-08-04       Impact factor: 4.530

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  13 in total

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8.  Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy.

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