Literature DB >> 23144344

Autologous adipose-tissue derived regenerative cells for the treatment of complex cryptoglandular fistula-in-ano: a report of three cases.

David W Borowski1, Talvinder S Gill, Anil K Agarwal, Pudhupalayam Bhaskar.   

Abstract

The treatment of complex fistulae-in-ano is challenging and often includes a number of operations due to high rates of recurrence. We report the successful treatment of three consecutive patients with long-standing cryptoglandular fistula-in-ano with a novel combination of mucosal advancement flap and adipose-tissue derived regenerative cells (ADRCs) from the stromal vascular fraction (SVF) obtained from a simple lipoaspiration procedure, using Celution technology. There was no operative morbidity; one patient who had a colostomy for faecal diversion has since undergone restoration of bowel continuity. All thee fistulae remain healed at 2-3-year follow-up. Lipofilling of cryptoglandular fistulae-in-ano with ADRC-enhanced lipofilling appears feasible and safe, and may add to the range of procedures that can be used to treat this difficult problem.

Entities:  

Mesh：

Year:  2012        PMID： 23144344      PMCID： PMC4544401          DOI： 10.1136/bcr-2012-006988

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  15 in total

1.  Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas.

Authors:  Hector Guadalajara; Dolores Herreros; Paloma De-La-Quintana; Jacobo Trebol; Mariano Garcia-Arranz; Damian Garcia-Olmo
Journal:  Int J Colorectal Dis       Date:  2011-11-09       Impact factor: 2.571

Review 2.  Multipotential differentiation of adipose tissue-derived stem cells.

Authors:  Brian M Strem; Kevin C Hicok; Min Zhu; Isabella Wulur; Zeni Alfonso; Ronda E Schreiber; John K Fraser; Marc H Hedrick
Journal:  Keio J Med       Date:  2005-09

Review 3.  The Surgisis AFP anal fistula plug: report of a consensus conference.

Authors: 
Journal:  Colorectal Dis       Date:  2007-11-19       Impact factor: 3.788

4.  Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion.

Authors:  Damian Garcia-Olmo; Dolores Herreros; Maria Pascual; Isabel Pascual; Paloma De-La-Quintana; Jacobo Trebol; Mariano Garcia-Arranz
Journal:  Int J Colorectal Dis       Date:  2008-08-12       Impact factor: 2.571

5.  LIFT procedure: a simplified technique for fistula-in-ano.

Authors:  A Rojanasakul
Journal:  Tech Coloproctol       Date:  2009-07-28       Impact factor: 3.781

6.  Characterization of adipose tissue-derived cells isolated with the Celution system.

Authors:  K Lin; Y Matsubara; Y Masuda; K Togashi; T Ohno; T Tamura; Y Toyoshima; K Sugimachi; M Toyoda; H Marc; A Douglas
Journal:  Cytotherapy       Date:  2008       Impact factor: 5.414

7.  Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial.

Authors:  R Pérez-Cano; J J Vranckx; J M Lasso; C Calabrese; B Merck; A M Milstein; E Sassoon; E Delay; E M Weiler-Mithoff
Journal:  Eur J Surg Oncol       Date:  2012-03-15       Impact factor: 4.424

8.  Anal fistula surgery. Factors associated with recurrence and incontinence.

Authors:  J Garcia-Aguilar; C Belmonte; W D Wong; S M Goldberg; R D Madoff
Journal:  Dis Colon Rectum       Date:  1996-07       Impact factor: 4.585

9.  Multilineage potential of adult human mesenchymal stem cells.

Authors:  M F Pittenger; A M Mackay; S C Beck; R K Jaiswal; R Douglas; J D Mosca; M A Moorman; D W Simonetti; S Craig; D R Marshak
Journal:  Science       Date:  1999-04-02       Impact factor: 47.728

10.  Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas.

Authors:  P Meinero; L Mori
Journal:  Tech Coloproctol       Date:  2011-10-15       Impact factor: 3.781
View more
  6 in total

1.  The Celution® System: Automated Processing of Adipose-Derived Regenerative Cells in a Functionally Closed System.

Authors:  John K Fraser; Kevin C Hicok; Rob Shanahan; Min Zhu; Scott Miller; Douglas M Arm
Journal:  Adv Wound Care (New Rochelle)       Date:  2014-01-01       Impact factor: 4.730

Review 2.  Complex anal fistula remains a challenge for colorectal surgeon.

Authors:  F Cadeddu; F Salis; G Lisi; I Ciangola; G Milito
Journal:  Int J Colorectal Dis       Date:  2015-01-09       Impact factor: 2.571

Review 3.  Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation.

Authors:  Pablo Bora; Anish S Majumdar
Journal:  Stem Cell Res Ther       Date:  2017-06-15       Impact factor: 6.832

4.  Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: a prospective case-control study.

Authors:  Yang Zhang; Min Ni; Chungen Zhou; Yehuang Wang; Yaxian Wang; Yang Shi; Jing Jin; Rui Zhang; Bin Jiang
Journal:  Stem Cell Res Ther       Date:  2020-11-10       Impact factor: 6.832

Review 5.  Trends in Treatment for Hemorrhoids, Fistula, and Anal Fissure: Go Along the Current Trends.

Authors:  Sung Hwan Hwang
Journal:  J Anus Rectum Colon       Date:  2022-07-28

6.  Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling.

Authors:  Yixin Ye; Xiaomei Zhang; Dongsheng Su; Yushuang Ren; Fuyi Cheng; Yunqi Yao; Gang Shi; Yanhong Ji; Shuang Chen; Pengyi Shi; Lei Dai; Xiaolan Su; Hongxin Deng
Journal:  Stem Cell Res Ther       Date:  2022-09-08       Impact factor: 8.079
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.