Literature DB >> 23143740

O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation.

Nicholas P Marotta1, Carli A Cherwien, Tharindumala Abeywardana, Matthew R Pratt.   

Abstract

Sweet relief: the Parkinson's disease- associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23143740     DOI： 10.1002/cbic.201200478

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  27 in total

Review 1.  Regulation of autophagy by protein post-translational modification.

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Journal:  Lab Invest       Date:  2014-11-03       Impact factor: 5.662

Review 2.  Nutrient regulation of signaling and transcription.

Authors:  Gerald W Hart
Journal:  J Biol Chem       Date:  2019-01-09       Impact factor: 5.157

3.  O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

Authors:  Yuka E Lewis; Ana Galesic; Paul M Levine; Cesar A De Leon; Natalie Lamiri; Caroline K Brennan; Matthew R Pratt
Journal:  ACS Chem Biol       Date:  2017-02-22       Impact factor: 5.100

Review 4.  Cell Biology and Pathophysiology of α-Synuclein.

Authors:  Jacqueline Burré; Manu Sharma; Thomas C Südhof
Journal:  Cold Spring Harb Perspect Med       Date:  2018-03-01       Impact factor: 6.915

5.  The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

Authors:  Kelly N Chuh; Anna R Batt; Balyn W Zaro; Narek Darabedian; Nicholas P Marotta; Caroline K Brennan; Arya Amirhekmat; Matthew R Pratt
Journal:  J Am Chem Soc       Date:  2017-05-31       Impact factor: 15.419

6.  Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis.

Authors:  Jennifer A Groves; Albert Lee; Gokben Yildirir; Natasha E Zachara
Journal:  Cell Stress Chaperones       Date:  2013-04-26       Impact factor: 3.667

7.  The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels.

Authors:  Cesar A De Leon; Paul M Levine; Timothy W Craven; Matthew R Pratt
Journal:  Biochemistry       Date:  2017-06-30       Impact factor: 3.162

8.  O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.

Authors:  Paul M Levine; Cesar A De Leon; Ana Galesic; Aaron Balana; Nicholas P Marotta; Yuka E Lewis; Matthew R Pratt
Journal:  Bioorg Med Chem       Date:  2017-04-29       Impact factor: 3.641

Review 9.  Cancer metabolism and elevated O-GlcNAc in oncogenic signaling.

Authors:  Zhiyuan Ma; Keith Vosseller
Journal:  J Biol Chem       Date:  2014-10-21       Impact factor: 5.157

10.  O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.

Authors:  Paul M Levine; Aaron T Balana; Emmanuel Sturchler; Cassandra Koole; Hiroshi Noda; Barbara Zarzycka; Eileen J Daley; Tin T Truong; Vsevolod Katritch; Thomas J Gardella; Denise Wootten; Patrick M Sexton; Patricia McDonald; Matthew R Pratt
Journal:  J Am Chem Soc       Date:  2019-08-28       Impact factor: 15.419
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