Literature DB >> 28108534

Cell Biology and Pathophysiology of α-Synuclein.

Jacqueline Burré1, Manu Sharma1, Thomas C Südhof2,3.   

Abstract

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) and other neurodegenerative disorders. Accumulation of misfolded oligomers and larger aggregates of α-synuclein defines multiple neurodegenerative diseases called synucleinopathies, but the mechanisms by which α-synuclein acts in neurodegeneration are unknown. Moreover, the normal cellular function of α-synuclein remains debated. In this perspective, we review the structural characteristics of α-synuclein, its developmental expression pattern, its cellular and subcellular localization, and its function in neurons. We also discuss recent progress on secretion of α-synuclein, which may contribute to its interneuronal spread in a prion-like fashion, and describe the neurotoxic effects of α-synuclein that are thought to be responsible for its role in neurodegeneration.
Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2018        PMID： 28108534      PMCID： PMC5519445          DOI： 10.1101/cshperspect.a024091

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  332 in total

1.  Structure and dynamics of micelle-bound human alpha-synuclein.

Authors:  Tobias S Ulmer; Ad Bax; Nelson B Cole; Robert L Nussbaum
Journal:  J Biol Chem       Date:  2004-12-22       Impact factor: 5.157

2.  Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.

Authors:  Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Muller; Helmut Jacobsen; Will Spooren; Babette Fuss; Barbara Mallon; Wendy B Macklin; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; Hans A Kretzschmar; Christian Haass
Journal:  EMBO Rep       Date:  2002-05-24       Impact factor: 8.807

3.  Induction of C/EBP beta and GADD153 expression by dopamine in human neuroblastoma cells. Relationship with alpha-synuclein increase and cell damage.

Authors:  Cristina Gómez-Santos; Marta Barrachina; Pol Giménez-Xavier; Esther Dalfó; Isidre Ferrer; Santiago Ambrosio
Journal:  Brain Res Bull       Date:  2005-02-15       Impact factor: 4.077

4.  alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.

Authors:  N Ostrerova; L Petrucelli; M Farrer; N Mehta; P Choi; J Hardy; B Wolozin
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

5.  Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.

Authors:  Eun Joo Kim; Jee Young Sung; Hyun Jung Lee; Hyewhon Rhim; Masato Hasegawa; Takeshi Iwatsubo; Do Sik Min; Jongsun Kim; Seung R Paik; Kwang Chul Chung
Journal:  J Biol Chem       Date:  2006-09-07       Impact factor: 5.157

Review 6.  Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.

Authors:  Mathias Jucker; Lary C Walker
Journal:  Ann Neurol       Date:  2011-10       Impact factor: 10.422

7.  Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.

Authors:  Xiangmin Peng; Xiangmin M Peng; Roya Tehranian; Paula Dietrich; Leonidas Stefanis; Ruth G Perez
Journal:  J Cell Sci       Date:  2005-07-19       Impact factor: 5.285

8.  Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization.

Authors:  S Nakajo; S Shioda; Y Nakai; K Nakaya
Journal:  Brain Res Mol Brain Res       Date:  1994-11

9.  Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Authors:  K Uéda; H Fukushima; E Masliah; Y Xia; A Iwai; M Yoshimoto; D A Otero; J Kondo; Y Ihara; T Saitoh
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

10.  Structural determinants of PLD2 inhibition by alpha-synuclein.

Authors:  Jacqueline E Payton; Richard J Perrin; Wendy S Woods; Julia M George
Journal:  J Mol Biol       Date:  2004-04-02       Impact factor: 5.469
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  108 in total

Review 1.  Genetics of Synucleinopathies.

Authors:  Robert L Nussbaum
Journal:  Cold Spring Harb Perspect Med       Date:  2018-06-01       Impact factor: 6.915

2.  The cellular prion protein (PrPC) as neuronal receptor for α-synuclein.

Authors:  Laura Urrea; Isidro Ferrer; Rosalina Gavín; José Antonio Del Río
Journal:  Prion       Date:  2017-07-31       Impact factor: 3.931

3.  Role of GSK3β/α-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells.

Authors:  Lizeng Li; Si Chen; Yue Wang; Xia Yue; Jingtao Xu; Weibing Xie; Pingming Qiu; Chao Liu; AiFeng Wang; Huijun Wang
Journal:  Toxicol Res (Camb)       Date:  2017-12-22       Impact factor: 3.524

4.  Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Authors:  Amanda L Woerman; Sabeen A Kazmi; Smita Patel; Atsushi Aoyagi; Abby Oehler; Kartika Widjaja; Daniel A Mordes; Steven H Olson; Stanley B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  2017-12-26       Impact factor: 11.205

Review 5.  α-Synuclein: Multiple System Atrophy Prions.

Authors:  Amanda L Woerman; Joel C Watts; Atsushi Aoyagi; Kurt Giles; Lefkos T Middleton; Stanley B Prusiner
Journal:  Cold Spring Harb Perspect Med       Date:  2018-07-02       Impact factor: 6.915

Review 6.  Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease.

Authors:  Darren M O'Hara; Suneil K Kalia; Lorraine V Kalia
Journal:  Br J Pharmacol       Date:  2018-06-03       Impact factor: 8.739

7.  Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.

Authors:  Gabriel E Vázquez-Vélez; Kristyn A Gonzales; Jean-Pierre Revelli; Carolyn J Adamski; Fatemeh Alavi Naini; Aleksandar Bajić; Evelyn Craigen; Ronald Richman; Sabrina M Heman-Ackah; Matthew J A Wood; Maxime W C Rousseaux; Huda Y Zoghbi
Journal:  J Neurosci       Date:  2019-11-20       Impact factor: 6.167

8.  Pre-aggregation kinetics and intermediates of α-synuclein monitored by the ESIPT probe 7MFE.

Authors:  Jonathan A Fauerbach; Thomas M Jovin
Journal:  Eur Biophys J       Date:  2017-12-18       Impact factor: 1.733

9.  α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.

Authors:  Qihui Wu; Hajime Takano; Dawn M Riddle; John Q Trojanowski; Douglas A Coulter; Virginia M-Y Lee
Journal:  J Neurosci       Date:  2019-04-29       Impact factor: 6.167

Review 10.  Endosomal sorting pathways in the pathogenesis of Parkinson's disease.

Authors:  Lindsey A Cunningham; Darren J Moore
Journal:  Prog Brain Res       Date:  2020-03-16       Impact factor: 2.453
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