CONTEXT: The epidemiology of prosthetic joint infection (PJI) in a population-based cohort has not been studied in the United States. OBJECTIVES: To provide an accurate assessment of the true incidence, secular trends, clinical manifestations, microbiology, and treatment outcomes of PJI in a population-based cohort. DESIGN: Historical cohort study. SETTING: Olmsted County, Minnesota. PARTICIPANTS: Residents who underwent total knee arthroplasty (TKA) or total hip arthroplasty (THA) between January 1, 1969, and December 31, 2007. METHODS: Incidence rates and trends in PJI were assessed using the Kaplan-Meier method and log-rank test, as were treatment outcomes among PJI case patients. RESULTS: A total of 7,375 THAs or TKAs were implanted in residents of Olmsted County during the study period. Seventy-five discrete joints in 70 individuals developed PJI, during a mean ± SD follow-up of [Formula: see text] years. The cumulative incidence of PJI was 0.5%, 0.8%, and 1.4% after 1, 5, and 10 years after arthroplasty, respectively. Overall, the rate of survival free of clinical failure after treatment of PJI was 76.8% (95% confidence interval [CI], 64.3-85.2) and 65.2% (95% CI, 33.1-76.2) at 3 and 5 years, respectively. The incidence and treatment outcomes did not significantly differ by decade of implantation, patient age at implantation, gender, or joint location. CONCLUSIONS: The incidence of PJI is relatively low in a population-based cohort and is a function of age of the prosthesis. Incidence trends and outcomes have not significantly changed over the past 40 years.
CONTEXT: The epidemiology of prosthetic joint infection (PJI) in a population-based cohort has not been studied in the United States. OBJECTIVES: To provide an accurate assessment of the true incidence, secular trends, clinical manifestations, microbiology, and treatment outcomes of PJI in a population-based cohort. DESIGN: Historical cohort study. SETTING: Olmsted County, Minnesota. PARTICIPANTS: Residents who underwent total knee arthroplasty (TKA) or total hip arthroplasty (THA) between January 1, 1969, and December 31, 2007. METHODS: Incidence rates and trends in PJI were assessed using the Kaplan-Meier method and log-rank test, as were treatment outcomes among PJI case patients. RESULTS: A total of 7,375 THAs or TKAs were implanted in residents of Olmsted County during the study period. Seventy-five discrete joints in 70 individuals developed PJI, during a mean ± SD follow-up of [Formula: see text] years. The cumulative incidence of PJI was 0.5%, 0.8%, and 1.4% after 1, 5, and 10 years after arthroplasty, respectively. Overall, the rate of survival free of clinical failure after treatment of PJI was 76.8% (95% confidence interval [CI], 64.3-85.2) and 65.2% (95% CI, 33.1-76.2) at 3 and 5 years, respectively. The incidence and treatment outcomes did not significantly differ by decade of implantation, patient age at implantation, gender, or joint location. CONCLUSIONS: The incidence of PJI is relatively low in a population-based cohort and is a function of age of the prosthesis. Incidence trends and outcomes have not significantly changed over the past 40 years.
Authors: R H Fitzgerald; D R Nolan; D M Ilstrup; R E Van Scoy; J A Washington; M B Coventry Journal: J Bone Joint Surg Am Date: 1977-10 Impact factor: 5.284
Authors: E F Berbari; A D Hanssen; M C Duffy; J M Steckelberg; D M Ilstrup; W S Harmsen; D R Osmon Journal: Clin Infect Dis Date: 1998-11 Impact factor: 9.079
Authors: Amar Rangan; Mark Falworth; Adam C Watts; Matthew Scarborough; Michael Thomas; Rohit Kulkarni; Jonathan Rees Journal: Shoulder Elbow Date: 2018-05-16
Authors: Angeles Estellés; Anne-Kathrin Woischnig; Keyi Liu; Robert Stephenson; Evelene Lomongsod; Da Nguyen; Jianzhong Zhang; Manfred Heidecker; Yifan Yang; Reyna J Simon; Edgar Tenorio; Stote Ellsworth; Anton Leighton; Stefan Ryser; Nina Khanna Gremmelmaier; Lawrence M Kauvar Journal: Antimicrob Agents Chemother Date: 2016-03-25 Impact factor: 5.191