BACKGROUND: Studies suggest that statins decrease mortality in COPD patients but it is unknown which patients might benefit most. OBJECTIVES: We investigated whether statins were associated with reduced mortality in COPD patients and whether effects differed according to baseline high-sensitivity C-reactive protein (hsCRP) concentration, a marker of systemic inflammation. METHODS: This nested case-control study was part of the Rotterdam Study, a prospective population-based cohort study among 7983 subjects ≥ 55 years. Using automated pharmacy records, we evaluated statin use of 363 cases (COPD patients who died during follow-up of 17 years) with 2345 age and sex matched controls (COPD patients who survived the follow-up period of the index case). RESULTS: Compared to never use, long-term statin use (>2 years) was associated with a 39% decreased risk of death in COPD patients. Stratified according to the level of systemic inflammation, long-term statin use was associated with a 78% reduced mortality if hsCRP level > 3 mg/L, versus a non significant 21% reduced mortality if hsCRP level ≤ 3 mg/L. CONCLUSIONS: Statin use is associated with a beneficial effect on all-cause mortality in COPD, depending on the baseline level of systemic inflammation.
BACKGROUND: Studies suggest that statins decrease mortality in COPDpatients but it is unknown which patients might benefit most. OBJECTIVES: We investigated whether statins were associated with reduced mortality in COPDpatients and whether effects differed according to baseline high-sensitivity C-reactive protein (hsCRP) concentration, a marker of systemic inflammation. METHODS: This nested case-control study was part of the Rotterdam Study, a prospective population-based cohort study among 7983 subjects ≥ 55 years. Using automated pharmacy records, we evaluated statin use of 363 cases (COPDpatients who died during follow-up of 17 years) with 2345 age and sex matched controls (COPDpatients who survived the follow-up period of the index case). RESULTS: Compared to never use, long-term statin use (>2 years) was associated with a 39% decreased risk of death in COPDpatients. Stratified according to the level of systemic inflammation, long-term statin use was associated with a 78% reduced mortality if hsCRP level > 3 mg/L, versus a non significant 21% reduced mortality if hsCRP level ≤ 3 mg/L. CONCLUSIONS: Statin use is associated with a beneficial effect on all-cause mortality in COPD, depending on the baseline level of systemic inflammation.
Authors: Albert Hofman; Sarwa Darwish Murad; Cornelia M van Duijn; Oscar H Franco; André Goedegebure; M Arfan Ikram; Caroline C W Klaver; Tamar E C Nijsten; Robin P Peeters; Bruno H Ch Stricker; Henning W Tiemeier; André G Uitterlinden; Meike W Vernooij Journal: Eur J Epidemiol Date: 2013-11-21 Impact factor: 8.082
Authors: Behzad Yeganeh; Emilia Wiechec; Sudharsana R Ande; Pawan Sharma; Adel Rezaei Moghadam; Martin Post; Darren H Freed; Mohammad Hashemi; Shahla Shojaei; Amir A Zeki; Saeid Ghavami Journal: Pharmacol Ther Date: 2014-02-26 Impact factor: 12.310
Authors: Gerard J Criner; John E Connett; Shawn D Aaron; Richard K Albert; William C Bailey; Richard Casaburi; J Allen D Cooper; Jeffrey L Curtis; Mark T Dransfield; MeiLan K Han; Barry Make; Nathaniel Marchetti; Fernando J Martinez; Dennis E Niewoehner; Paul D Scanlon; Frank C Sciurba; Steven M Scharf; Don D Sin; Helen Voelker; George R Washko; Prescott G Woodruff; Stephen C Lazarus Journal: N Engl J Med Date: 2014-05-18 Impact factor: 91.245