Literature DB >> 23139178

Double-effector nanoparticles: a synergistic approach to apoptotic hyperthermia.

Dongwon Yoo1, Heeyeong Jeong, Christian Preihs, Jin-sil Choi, Tae-Hyun Shin, Jonathan L Sessler, Jinwoo Cheon.   

Abstract

Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm(3)) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23139178      PMCID： PMC3724511          DOI： 10.1002/anie.201206400

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  32 in total

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