Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.

Literature DB >> 12510321

Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.

Darren Magda¹, Nikolay Gerasimchuk, Philip Lecane, Richard A Miller, John E Biaglow, Jonathan L Sessler.

Abstract

Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12510321 DOI： 10.1039/b208760j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

10 in total

Review 1. Texaphyrins: tumor localizing redox active expanded porphyrins.

Authors: Jonathan F Arambula; Christian Preihs; Derric Borthwick; Darren Magda; Jonathan L Sessler
Journal: Anticancer Agents Med Chem Date: 2011-02 Impact factor: 2.505

2. Texaphyrins and water-soluble zinc(II) ionophores: development, mechanism of anticancer activity, and synergistic effects.

Authors: Christian Preihs; Darren J Magda; Jonathan L Sessler
Journal: Bioinorg React Mech Date: 2013-12-01

3. New polyethyleneglycol-functionalized texaphyrins: synthesis and in vitro biological studies.

Authors: Wen-Hao Wei; Zhong Wang; Toshihisa Mizuno; Cecilia Cortez; Lei Fu; Mint Sirisawad; Louie Naumovski; Darren Magda; Jonathan L Sessler
Journal: Dalton Trans Date: 2006-01-24 Impact factor: 4.390

4. Photoinduced reduction of Pt(IV) within an anti-proliferative Pt(IV)-texaphyrin conjugate.

Authors: Grégory Thiabaud; Jonathan F Arambula; Zahid H Siddik; Jonathan L Sessler
Journal: Chemistry Date: 2014-06-24 Impact factor: 5.236

5. The novel expanded porphyrin, motexafin gadolinium, combined with [90Y]ibritumomab tiuxetan for relapsed/refractory non-Hodgkin's lymphoma: preclinical findings and results of a phase I trial.

Authors: Andrew M Evens; William G Spies; Irene B Helenowski; David Patton; Stewart Spies; Borko D Jovanovic; Sarah Miyata; Elizabeth Hamilton; Daina Variakojis; Jun Chen; Louie Naumovski; Steven T Rosen; Jane N Winter; Richard A Miller; Leo I Gordon
Journal: Clin Cancer Res Date: 2009-10-13 Impact factor: 12.531

6. Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents.

Authors: Grégory Thiabaud; Guangan He; Sajal Sen; Kathryn A Shelton; Wallace B Baze; Luke Segura; Julie Alaniz; Ruben Munoz Macias; Greg Lyness; Alan B Watts; Hyun Min Kim; Hyunseung Lee; Mi Young Cho; Kwan Soo Hong; Rick Finch; Zahid H Siddik; Jonathan F Arambula; Jonathan L Sessler
Journal: Proc Natl Acad Sci U S A Date: 2020-03-16 Impact factor: 11.205

Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.

Review 1. Texaphyrins: tumor localizing redox active expanded porphyrins.

2. Texaphyrins and water-soluble zinc(II) ionophores: development, mechanism of anticancer activity, and synergistic effects.

3. New polyethyleneglycol-functionalized texaphyrins: synthesis and in vitro biological studies.

4. Photoinduced reduction of Pt(IV) within an anti-proliferative Pt(IV)-texaphyrin conjugate.

5. The novel expanded porphyrin, motexafin gadolinium, combined with [90Y]ibritumomab tiuxetan for relapsed/refractory non-Hodgkin's lymphoma: preclinical findings and results of a phase I trial.

6. Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents.

7. Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator.

8. Double-effector nanoparticles: a synergistic approach to apoptotic hyperthermia.

Review 9. Motexafin gadolinium induces oxidative stress and apoptosis in hematologic malignancies.

10. Oxalate production via oxidation of ascorbate rather than reduction of carbon dioxide.