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Literature DB >> 23138557

[Glycosylation-dependent effector function of IgG antibodies].

Abstract

The Fc fragments of pathogenic IgG autoantibodies in patients with rheumatoid arthritis are low-galactosylated and low-sialylated. In contrast, high-galactosylated and high-sialylated antigen-specific IgG antibodies are sufficient to inhibit a pro-inflammatory immune response in an antigen-specific manner and might be a promising therapeutic tool to re-establish tolerance against defined self-antigens in autoimmune patients.

Entities: Disease Species

Mesh：

Substances：

Year: 2012 PMID： 23138557 DOI： 10.1007/s00393-012-1007-7

Source DB: PubMed Journal: Z Rheumatol ISSN： 0340-1855 Impact factor: 1.372

14 in total

1. Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid.

Authors: Hans U Scherer; Diane van der Woude; Andreea Ioan-Facsinay; Hanane el Bannoudi; Leendert A Trouw; Jun Wang; Thomas Häupl; Gerd-R Burmester; André M Deelder; Tom W J Huizinga; Manfred Wuhrer; René E M Toes
Journal: Arthritis Rheum Date: 2010-06

2. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation.

Authors: Yoshikatsu Kaneko; Falk Nimmerjahn; Jeffrey V Ravetch
Journal: Science Date: 2006-08-04 Impact factor: 47.728

3. Identification of a receptor required for the anti-inflammatory activity of IVIG.

Authors: Robert M Anthony; Fredrik Wermeling; Mikael C I Karlsson; Jeffrey V Ravetch
Journal: Proc Natl Acad Sci U S A Date: 2008-11-26 Impact factor: 11.205

Review 4. Anti-inflammatory actions of intravenous immunoglobulin.

Authors: Falk Nimmerjahn; Jeffrey V Ravetch
Journal: Annu Rev Immunol Date: 2008 Impact factor: 28.527

5. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.

Authors: Robert M Anthony; Falk Nimmerjahn; David J Ashline; Vernon N Reinhold; James C Paulson; Jeffrey V Ravetch
Journal: Science Date: 2008-04-18 Impact factor: 47.728

6. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

Authors: Robert M Anthony; Toshihiko Kobayashi; Fredrik Wermeling; Jeffrey V Ravetch
Journal: Nature Date: 2011-06-19 Impact factor: 49.962

7. TLR9 in peritoneal B-1b cells is essential for production of protective self-reactive IgM to control Th17 cells and severe autoimmunity.

Authors: Alexander D Stoehr; Carolin T Schoen; Maria M M Mertes; Susanne Eiglmeier; Vivien Holecska; Alexandra K Lorenz; Tim Schommartz; Anna-Lena Schoen; Constanze Hess; André Winkler; Hedda Wardemann; Marc Ehlers
Journal: J Immunol Date: 2011-08-22 Impact factor: 5.422

8. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.

Authors: Prapaporn Pisitkun; Jonathan A Deane; Michael J Difilippantonio; Tatyana Tarasenko; Anne B Satterthwaite; Silvia Bolland
Journal: Science Date: 2006-05-18 Impact factor: 47.728

9. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

Authors: Christian M Karsten; Manoj K Pandey; Julia Figge; Regina Kilchenstein; Philip R Taylor; Marcela Rosas; Jacqueline U McDonald; Selinda J Orr; Markus Berger; Dominique Petzold; Veroniqué Blanchard; André Winkler; Constanze Hess; Delyth M Reid; Irina V Majoul; Richard T Strait; Nathaniel L Harris; Gabriele Köhl; Eva Wex; Ralf Ludwig; Detlef Zillikens; Falk Nimmerjahn; Fred D Finkelman; Gordon D Brown; Marc Ehlers; Jörg Köhl
Journal: Nat Med Date: 2012-09 Impact factor: 53.440