PURPOSE: While pituitary adenomas are common, pituitary carcinomas are rare. It is unclear whether pituitary carcinomas arise de novo or evolve from adenomas. METHODS: We studied the clinical characteristics and tissue samples from eight pituitary surgeries and the autopsy from a patient with pituitary carcinoma. A 16-year-old female patient was diagnosed with an aggressive Crooke cell macroadenoma. Following transsphenoidal surgery, clinical signs of Cushing disease quickly reappeared. During the 14-year course of the illness, eight pituitary surgeries, three courses of extracranial irradiation and two (90) Yttrium-DOTATOC treatments were undertaken. A bilateral adrenalectomy was performed. The patient died of metastatic disease and uncontrolled hypercortisolism due to an adrenal remnant. A systematic morphologic study (histologic staining, electron microscopy) of all available surgical and autopsy specimens was undertaken. RESULTS: Brisk mitotic activity, high Ki-67 and p53 immunolabelling were present in the pituitary samples from the onset. High proportion of tumour cells showed irregular nuclei and large nucleoli, and gradual increase in MGMT staining was observed. The tumour remained of Crooke cell type throughout the course. Autopsy disclosed a postirradiation sarcoma in the pituitary area. CONCLUSIONS: The question whether pituitary carcinomas arise de novo or transform from an adenoma cannot be answered at present with certainty.
PURPOSE: While pituitary adenomas are common, pituitary carcinomas are rare. It is unclear whether pituitary carcinomas arise de novo or evolve from adenomas. METHODS: We studied the clinical characteristics and tissue samples from eight pituitary surgeries and the autopsy from a patient with pituitary carcinoma. A 16-year-old female patient was diagnosed with an aggressive Crooke cell macroadenoma. Following transsphenoidal surgery, clinical signs of Cushing disease quickly reappeared. During the 14-year course of the illness, eight pituitary surgeries, three courses of extracranial irradiation and two (90) Yttrium-DOTATOC treatments were undertaken. A bilateral adrenalectomy was performed. The patient died of metastatic disease and uncontrolled hypercortisolism due to an adrenal remnant. A systematic morphologic study (histologic staining, electron microscopy) of all available surgical and autopsy specimens was undertaken. RESULTS: Brisk mitotic activity, high Ki-67 and p53 immunolabelling were present in the pituitary samples from the onset. High proportion of tumour cells showed irregular nuclei and large nucleoli, and gradual increase in MGMT staining was observed. The tumour remained of Crooke cell type throughout the course. Autopsy disclosed a postirradiation sarcoma in the pituitary area. CONCLUSIONS: The question whether pituitary carcinomas arise de novo or transform from an adenoma cannot be answered at present with certainty.
Authors: G Giuffrida; F Ferraù; R Laudicella; O R Cotta; E Messina; F Granata; F F Angileri; A Vento; A Alibrandi; S Baldari; S Cannavò Journal: Endocr Connect Date: 2019-05-01 Impact factor: 3.335
Authors: Andrés Coca-Pelaz; Justin A Bishop; Nina Zidar; Abbas Agaimy; Eloisa Maria Mello Santiago Gebrim; Vanni Mondin; Oded Cohen; Primož Strojan; Alessandra Rinaldo; Ashok R Shaha; Remco de Bree; Marc Hamoir; Antti A Mäkitie; Luiz P Kowalski; Nabil F Saba; Alfio Ferlito Journal: Cancer Manag Res Date: 2022-03-09 Impact factor: 3.989
Authors: Sam Ng; Mahmoud Messerer; Julien Engelhardt; Michaël Bruneau; Jan Frederick Cornelius; Luigi Maria Cavallo; Giulia Cossu; Sebastien Froelich; Torstein R Meling; Dimitrios Paraskevopoulos; Henry W S Schroeder; Marcos Tatagiba; Idoya Zazpe; Moncef Berhouma; Roy T Daniel; Edward R Laws; Engelbert Knosp; Michael Buchfelder; Henri Dufour; Stéphane Gaillard; Timothée Jacquesson; Emmanuel Jouanneau Journal: Acta Neurochir (Wien) Date: 2021-08-08 Impact factor: 2.816