Literature DB >> 23132828

Real-time monitoring of protein conformational dynamics in solution using kinetic capillary electrophoresis.

Christopher M Clouthier1, Gleb G Mironov, Victor Okhonin, Maxim V Berezovski, Jeffrey W Keillor.   

Abstract

Conformational analysis: Capillary electrophoresis (CE) allows for the rapid separation of slowly interconverting protein conformers. Kinetic analysis (k(open), k(closed), and K(d)) of electropherograms in the presence and absence of effector ligands allows the measurement of kinetic and thermodynamic constants associated with conformational changes and ligand binding.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23132828     DOI： 10.1002/anie.201205575

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  13 in total

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