Literature DB >> 23131666

Two faces of brd4: mitotic bookmark and transcriptional lynchpin.

Ballachanda N Devaiah1, Dinah S Singer.   

Abstract

The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.

Entities:  

Keywords:  Atypical kinase; BET protein; BRD4; CTD kinase; P-TEFb; RNA Polymerase II

Mesh：

Substances：

Year:  2012        PMID： 23131666      PMCID： PMC3644036          DOI： 10.4161/trns.22542

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  32 in total

1.  A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.

Authors:  A Dey; J Ellenberg; A Farina; A E Coleman; T Maruyama; S Sciortino; J Lippincott-Schwartz; K Ozato
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.

Authors:  Ballachanda N Devaiah; Brian A Lewis; Natasha Cherman; Michael C Hewitt; Brian K Albrecht; Pamela G Robey; Keiko Ozato; Robert J Sims; Dinah S Singer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

3.  The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

Authors:  Shaila Rahman; Mathew E Sowa; Matthias Ottinger; Jennifer A Smith; Yang Shi; J Wade Harper; Peter M Howley
Journal:  Mol Cell Biol       Date:  2011-05-09       Impact factor: 4.272

4.  Regulation of aurora B expression by the bromodomain protein Brd4.

Authors:  Jianxin You; Qing Li; Chong Wu; Jina Kim; Matthias Ottinger; Peter M Howley
Journal:  Mol Cell Biol       Date:  2009-07-13       Impact factor: 4.272

5.  Bromodomain 4 activation predicts breast cancer survival.

Authors:  Nigel P S Crawford; Jude Alsarraj; Luanne Lukes; Renard C Walker; Jennifer S Officewala; Howard H Yang; Maxwell P Lee; Keiko Ozato; Kent W Hunter
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-21       Impact factor: 11.205

6.  BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.

Authors:  Christopher A French; Isao Miyoshi; Ichiro Kubonishi; Holcombe E Grier; Antonio R Perez-Atayde; Jonathan A Fletcher
Journal:  Cancer Res       Date:  2003-01-15       Impact factor: 12.701

7.  Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.

Authors:  Friederike Vollmuth; Wulf Blankenfeldt; Matthias Geyer
Journal:  J Biol Chem       Date:  2009-10-13       Impact factor: 5.157

8.  Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition.

Authors:  Nadine Czudnochowski; Christian A Bösken; Matthias Geyer
Journal:  Nat Commun       Date:  2012-05-15       Impact factor: 14.919

Review 9.  Updating the RNA polymerase CTD code: adding gene-specific layers.

Authors:  Sylvain Egloff; Martin Dienstbier; Shona Murphy
Journal:  Trends Genet       Date:  2012-05-21       Impact factor: 11.639

10.  Updating the CTD Story: From Tail to Epic.

Authors:  Bartlomiej Bartkowiak; April L Mackellar; Arno L Greenleaf
Journal:  Genet Res Int       Date:  2011-10-15
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  40 in total

1.  Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Authors:  Hideyuki Yoshida; Kushagra Bansal; Uwe Schaefer; Trevor Chapman; Inmaculada Rioja; Irina Proekt; Mark S Anderson; Rab K Prinjha; Alexander Tarakhovsky; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-27       Impact factor: 11.205

2.  Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.

Authors:  Brandon L Crowe; Ross C Larue; Chunhua Yuan; Sonja Hess; Mamuka Kvaratskhelia; Mark P Foster
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

3.  Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division.

Authors:  Alice Grob; Brian McStay
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 4.  BET and EZH2 Inhibitors: Novel Approaches for Targeting Cancer.

Authors:  Sofia Genta; Maria Cristina Pirosa; Anastasios Stathis
Journal:  Curr Oncol Rep       Date:  2019-02-04       Impact factor: 5.075

Review 5.  BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.

Authors:  Dequina A Nicholas; Guillaume Andrieu; Katherine J Strissel; Barbara S Nikolajczyk; Gerald V Denis
Journal:  Cell Mol Life Sci       Date:  2016-08-04       Impact factor: 9.261

6.  New role for histone deacetylase 9 in atherosclerosis and inflammation.

Authors:  Jonathan D Smith
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-09       Impact factor: 8.311

7.  The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.

Authors:  Yu Xiong; Linli Li; Liting Zhang; Yangyang Cui; Chengyong Wu; Hui Li; Kai Chen; Qiuyuan Yang; Rong Xiang; Yiguo Hu; Shile Huang; Yuquan Wei; Shengyong Yang
Journal:  Cell Death Differ       Date:  2019-01-15       Impact factor: 15.828

8.  Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.

Authors:  Xiangming Hu; Xiaodong Lu; Runzhong Liu; Nanping Ai; Zhenhua Cao; Yannan Li; Jiangfang Liu; Bin Yu; Kai Liu; Huiping Wang; Chao Zhou; Yu Wang; Aidong Han; Feng Ding; Ruichuan Chen
Journal:  J Biol Chem       Date:  2014-06-17       Impact factor: 5.157

Review 9.  Epigenetic regulation of EBV and KSHV latency.

Authors:  Horng-Shen Chen; Fang Lu; Paul M Lieberman
Journal:  Curr Opin Virol       Date:  2013-04-16       Impact factor: 7.090

10.  The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.

Authors:  Hassen S Wollebo; Anna Bellizzi; Dominique H Cossari; Julian Salkind; Mahmut Safak; Martyn K White
Journal:  J Neurovirol       Date:  2016-03-23       Impact factor: 2.643
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