Effect of isometamidium hydrochloride on Trypanosoma evansi infections in rats.

Effect of Isometamidium treatment of rats infected with Trypanosoma evansi was studied under experimental condition. The infection resulted in 100 per cent mortality by 7 day post treatment (DPT) in the infected untreated rats (Gr.II) and Isometamidium-HCl exerted 90 percent anti-trypanosomal efficacy. Haematological studies of all the groups on 3 day post infection (DPI) and on 7 DPT showed that T. evansi infection significantly decreased haematological values, however Isometamidium treatment significantly (P < 0.05) improved Hb and PCV without any significant changes in TEC and TLC values. Serum AST and ALT activities were significantly (P < 0.01) higher in the treated rats compared to healthy rats. Treatment with Isometamidium-HCl significantly improved blood glucose level but decreased creatinine level compared to pretreatment values. There was no significant change in BUN level of treated rats but the value was higher (P < 0.01) compared to healthy rats.