Literature DB >> 23125715

3-(2-Chloro-3-hy-droxy-4-meth-oxy-phen-yl)-1-(4,5-dimeth-oxy-2-methyl-phen-yl)prop-2-en-1-one.

U H Patel1, S A Gandhi, V M Barot, M C Patel.   

Abstract

The title compound, C(19)H(19)ClO(5), is a chloro derivative of a biologically significant chalcone family. The mean plane of the two substituted benzene rings are twisted by 55.33 (8)° with respect to each other. An intra-molecular C-H⋯Cl hydrogen bond generates an S(5) graph-set motif. In the crystal, a bifurcated O-H⋯(O,O) hydrogen bond leads to an R(1) (2)(5) graph-set motif and to the formation of zigzag chains propagating along the c-axis direction. A weak π-π inter-action involving the methyl-phenyl rings [centroid-centroid distance = 3.8185 (10) Å] and C-H⋯π inter-actions also occur.

Entities:  

Year:  2012        PMID: 23125715      PMCID: PMC3470302          DOI: 10.1107/S1600536812038275

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  6 in total

1.  C--H...O hydrogen-bonding and C--H...pi interactions in 3-(4-fluorophenyl)-1,5,7-trimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione.

Authors:  Urmila H Patel; Pinal D Patel; Neha Thakker
Journal:  Acta Crystallogr C       Date:  2007-05-11       Impact factor: 1.172

2.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

3.  Antifungal activity of chalcones: a mechanistic study using various yeast strains.

Authors:  K L Lahtchev; D I Batovska; St P Parushev; V M Ubiyvovk; A A Sibirny
Journal:  Eur J Med Chem       Date:  2008-01-12       Impact factor: 6.514

4.  Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.

Authors:  Ewelina Szliszka; Zenon P Czuba; Bogdan Mazur; Lukasz Sedek; Andrzej Paradysz; Wojciech Krol
Journal:  Int J Mol Sci       Date:  2009-12-24       Impact factor: 5.923

5.  Structural antitumoral activity relationships of synthetic chalcones.

Authors:  Cesar Echeverria; Juan Francisco Santibañez; Oscar Donoso-Tauda; Carlos A Escobar; Rodrigo Ramirez-Tagle
Journal:  Int J Mol Sci       Date:  2009-01-09       Impact factor: 6.208

6.  Structure validation in chemical crystallography.

Authors:  Anthony L Spek
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  6 in total
  2 in total

1.  1-[3-(2-Benz-yloxy-6-hy-droxy-4-methyl-phen-yl)-5-[3,5-bis-(tri-fluoro-meth-yl)phen-yl]-4,5-di-hydro-1H-pyrazol-1-yl]propane-1-one.

Authors:  U H Patel; S A Gandhi; V M Barot; N V S Varma
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-04

2.  5-(4-Chloro-phen-yl)-7-(4-methyl-phen-yl)-4-(pyrrolidin-1-yl)-7H-pyrrolo-[2,3-d]pyrimidine.

Authors:  Urmila H Patel; Rajesh D Modh; Dhaval A Shah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-07-20
  2 in total

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